| Use of lipid-lowering drugs | |||||
---|---|---|---|---|---|---|
COR (95% CI) | P value | Model 1 | Model 2 | |||
AOR (95% CI) | P value a | AOR (95% CI) | P value b | |||
Age, per year | 1.11 (1.08–1.14) | < 0.001 | 1.12 (1.08–1.16) | <  0.001 | 1.12 (1.08–1.16) | <  0.001 |
Diabetes duration, per year | 1.05 (1.03–1.07) | < 0.001 | 1.00 (0.97–1.03) | 0.94 | 1.00 (0.97–1.03) | 0.85 |
Sex, women | 0.8 (0.5–1.4) | 0.48 | – | – | – | – |
EN-RAGE, Lg10, per unit | 0.5 (0.3–1.0) | 0.059 | 0.4 (0.2–1.0) | 0.046 | – | – |
sRAGE, Lg10, per unit | 1.7 (0.9–3.6) | 0.13 | 3.5 (1.4, 9.1) | 0.009 | – | – |
EN-RAGE/sRAGE ratio, Lg10, per unit | 0.5 (0.3–0.8) | 0.010 | – | – | 0.3 (0.2–0.7) | 0.003 |
CRP, Lg10, per unit | 1.0 (0.5–1.7) | 0.87 | – | – | – | – |
HbA1c, per mmol/mol | 1.02 (1.00–1.04) | 0.026 | 1.01 (0.99–1.04) | 0.34 | 1.01 (0.99–1.04 | 0.34 |
Total cholesterol, Lg10, per unit | 0.8 (0.1–12.4) | 0.89 | – | – | – | – |
Triglycerides, Lg10, per unit | 3.2 (1.1–9.5) | 0.038 | 3.5 (1.4–9.1) | 0.029 | 5.0 (1.2–21.3) | 0.030 |
LDL-cholesterol, per mmol/L | 0.9 (0.7–1.3) | 0.72 | – | – | – | – |
HDL-cholesterol, Lg10, per unit | 1.3 (0.2–11.5) | 0.79 | – | – | – | – |
S-creatinine, Lg10, per unit | 11.4 (0.9–150) | 0.064 | 0.8 (0.02–36) | 0.92 | 1.2 (0.03–47) | 0.93 |
Abdominal obesity | 2.3 (1.2–4.4) | 0.014 | 2.1 (0.8–5.1) | 0.11 | 2.0 (0.8–4.9) | 0.12 |
Hypoglycemia, severe episodes | 1.7 (0.5–5.5) | 0.38 | – | – | – | – |
Systolic BP, per mm Hg | 1.05 (1.02–1.07) | < 0.001 | 0.99 (0.96–1.02) | 0.55 | 0.99 (0.96–1.02) | 0.56 |
Diastolic BP, per mm Hg | 1.02 (0.98–1.05) | 0.38 | – | – | – | – |
Depression | 1.1 (0.4–2.4) | 0.79 | – | – | – | – |
Smoking | 1.0 (0.4–2.2) | 0.96 | – | – | – | – |
Physical inactivity | 0.6 (0.2–1.2) | 0.15 | 0.9 (0.3–3.0) | 0.93 | 1.0 (0.3–3.1) | 0.94 |
Continuous subcutaneous insulin infusion | 0.8 (0.3–1.8) | 0.53 | – | – | – | – |
Antihypertensive drugs | 3.2 (1.9–5.4) | < 0.001 | 1.6 (0.8–3.2) | 0.19 | 1.6 (0.8–3.1) | 0.21 |
Antidepressants | 2.7 (1.1–6.9) | 0.035 | 1.3 (0.4–4.5) | 0.64 | 1.4 (0.4–4.7) | 0.59 |
Corticosteroids, nasal or inhaled | 1.2 (0.5–2.7) | 0.66 | – | – | – | – |
Cardiovascular complications | 11.3 (1.4–90 | 0.022 | 1.3 (0.1–12.5) | 0.82 | 1.4 (0.2–13.4) | 0.75 |