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Table 3 Associations with LLD presented for two separate models

From: Higher levels of the soluble receptor for advanced glycation end products and lower levels of the extracellular newly identified receptor for advanced glycation end products were associated with lipid-lowering drugs in patients with type 1 diabetes: a comparative cross-sectional study

 

Use of lipid-lowering drugs

COR (95% CI)

P value

Model 1

Model 2

AOR (95% CI)

P value a

AOR (95% CI)

P value b

Age, per year

1.11 (1.08–1.14)

< 0.001

1.12 (1.08–1.16)

<  0.001

1.12 (1.08–1.16)

<  0.001

Diabetes duration, per year

1.05 (1.03–1.07)

< 0.001

1.00 (0.97–1.03)

0.94

1.00 (0.97–1.03)

0.85

Sex, women

0.8 (0.5–1.4)

0.48

–

–

–

–

EN-RAGE, Lg10, per unit

0.5 (0.3–1.0)

0.059

0.4 (0.2–1.0)

0.046

–

–

sRAGE, Lg10, per unit

1.7 (0.9–3.6)

0.13

3.5 (1.4, 9.1)

0.009

–

–

EN-RAGE/sRAGE ratio, Lg10, per unit

0.5 (0.3–0.8)

0.010

–

–

0.3 (0.2–0.7)

0.003

CRP, Lg10, per unit

1.0 (0.5–1.7)

0.87

–

–

–

–

HbA1c, per mmol/mol

1.02 (1.00–1.04)

0.026

1.01 (0.99–1.04)

0.34

1.01 (0.99–1.04

0.34

Total cholesterol, Lg10, per unit

0.8 (0.1–12.4)

0.89

–

–

–

–

Triglycerides, Lg10, per unit

3.2 (1.1–9.5)

0.038

3.5 (1.4–9.1)

0.029

5.0 (1.2–21.3)

0.030

LDL-cholesterol, per mmol/L

0.9 (0.7–1.3)

0.72

–

–

–

–

HDL-cholesterol, Lg10, per unit

1.3 (0.2–11.5)

0.79

–

–

–

–

S-creatinine, Lg10, per unit

11.4 (0.9–150)

0.064

0.8 (0.02–36)

0.92

1.2 (0.03–47)

0.93

Abdominal obesity

2.3 (1.2–4.4)

0.014

2.1 (0.8–5.1)

0.11

2.0 (0.8–4.9)

0.12

Hypoglycemia, severe episodes

1.7 (0.5–5.5)

0.38

–

–

–

–

Systolic BP, per mm Hg

1.05 (1.02–1.07)

< 0.001

0.99 (0.96–1.02)

0.55

0.99 (0.96–1.02)

0.56

Diastolic BP, per mm Hg

1.02 (0.98–1.05)

0.38

–

–

–

–

Depression

1.1 (0.4–2.4)

0.79

–

–

–

–

Smoking

1.0 (0.4–2.2)

0.96

–

–

–

–

Physical inactivity

0.6 (0.2–1.2)

0.15

0.9 (0.3–3.0)

0.93

1.0 (0.3–3.1)

0.94

Continuous subcutaneous insulin infusion

0.8 (0.3–1.8)

0.53

–

–

–

–

Antihypertensive drugs

3.2 (1.9–5.4)

< 0.001

1.6 (0.8–3.2)

0.19

1.6 (0.8–3.1)

0.21

Antidepressants

2.7 (1.1–6.9)

0.035

1.3 (0.4–4.5)

0.64

1.4 (0.4–4.7)

0.59

Corticosteroids, nasal or inhaled

1.2 (0.5–2.7)

0.66

–

–

–

–

Cardiovascular complications

11.3 (1.4–90

0.022

1.3 (0.1–12.5)

0.82

1.4 (0.2–13.4)

0.75

  1. a, b Multiple regression analyses (Backward: Wald): N = a, b 239; Nagelkerke R Square a 0.391/b 0.389
  2. Hosmer and Lemeshow Test a 0.024/b 0.010. For missing values, see Tables 1 and 2