Table 1 Baseline characteristics of all patients
Statin user (N = 86,188) | Statin non-user (N = 86,188) | P value | |
|---|---|---|---|
Age (year-old) | 64.4 ± 12.9 | 64.5 ± 13.1 | 0.998 |
Sex | 1.000 | ||
Male (%) | 39,302 (45.6) | 39,302 (45.6) | |
Female (%) | 46,886 (54.4) | 46,886 (54.4) | |
Index date (years) | 4.5 | 4.5 | 1.000 |
Charlson score (Mean + SD) | 4.1 + 1.0 | 3.8 + 0.9 | 0.902 |
Comorbidities (n, %) | |||
Hypertension (%) | 19,909 (23.1) | 10,170 (11.8) | < 0.001 |
CAD (%) | 3706 (4.3) | 1724 (2.0) | < 0.001 |
CHF (%) | 371 (0.4) | 259 (0.3) | 0.663 |
CKD (%) | 3017 (3.5) | 1034 (1.2) | < 0.001 |
DM (%) | 6206 (7.2) | 2758 (3.2) | < 0.001 |
Dementia (%) | 172 (0.2) | 431 (0.5) | 0.526 |
Cancer (%) | 1724 (2.0) | 2591 (3.0) | 0.450 |
Hyperthyroidism (%) | 172 (0.2) | 1120 (1.3) | 0.011 |
Obesity (%) | 259 (0.3) | 2155 (2.5) | 0.005 |
Depression (%) | 1034 (1.2) | 948 (1.1) | 0.978 |
Rheumatoid arthritis | 690 (0.8) | 690 (0.8) | 1.000 |
Alcoholism (%) | 171 (0.2) | 431 (0.5) | 0.669 |
Concurrent medications (n) | |||
Loop diuretics (%) | 9912 (11.5) | 5171 (6.0) | < 0.001 |
Thiazide diuretics (%) | 4482 (5.2) | 2155 (2.5) | < 0.001 |
Beta-blockers (%) | 5731 (6.5) | 5688 (6.6) | 0.870 |
DHP CCBs (%) | 10,429 (12.1) | 9308 (10.8) | 0.661 |
Non-DHP CCBs (%) | 3275 (3.8) | 1551 (1.8) | < 0.001 |
Alph-blockers (%) | 1551 (1.8) | 517 (0.6) | < 0.001 |
ACE inhibitors (%) | 3189 (3.7) | 3792 (4.4) | 0.047 |
ARBs (%) | 8274 (9.6) | 8188 (9.5) | 0.916 |
Benzodiazepines (%) | 25,253 (29.3) | 24,908 (28.9) | 0.330 |
SSRI (%) | 862 (1.0) | 30 (0.0) | < 0.001 |
Glucocorticoids (%) | 29,304 (34.0) | 24,564 (28.5) | < 0.001 |
Opioid analgesics (%) | 5430 (6.3) | 5688 (6.6) | 0.222 |
HRT (%) | 603 (0.7) | 1207 (1.4) | < 0.001 |