TY - JOUR AU - Suzuki-Kemuriyama, Noriko AU - Abe, Akari AU - Uno, Kinuko AU - Ogawa, Shuji AU - Watanabe, Atsushi AU - Sano, Ryuhei AU - Yuki, Megumi AU - Miyajima, Katsuhiro AU - Nakae, Dai PY - 2020 DA - 2020/12/14 TI - A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a choline-deficient, methionine-lowered, L-amino acid-defined, high-fat diet JO - Lipids in Health and Disease SP - 251 VL - 19 IS - 1 AB - Nonalcoholic steatohepatitis (NASH) is a form of liver disease characterized by steatosis, necroinflammation, and fibrosis, resulting in cirrhosis and cancer. Efforts have focused on reducing the intake of trans fatty acids (TFAs) because of potential hazards to human health and the increased risk for NASH. However, the health benefits of reducing dietary TFAs have not been fully elucidated. Here, the effects of TFAs vs. a substitute on NASH induced in mice by feeding a choline-deficient, methionine-lowered, L-amino acid-defined, high-fat diet (CDAA-HF) were investigated. SN - 1476-511X UR - https://doi.org/10.1186/s12944-020-01423-3 DO - 10.1186/s12944-020-01423-3 ID - Suzuki-Kemuriyama2020 ER -