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Fig. 2 | Lipids in Health and Disease

Fig. 2

From: A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a choline-deficient, methionine-lowered, L-amino acid-defined, high-fat diet

Fig. 2

Proliferative liver lesions at the end of week 26. Macroscopic features of the liver from mice (a). Microscopic features (hepatocellular hyperplasia and adenoma) of hepatic proliferative lesions of mice fed the CDAA-HF-T(−) diet (b). Histopathological features of PCNA staining. PCNA-positive index in normal liver tissue of control animals, nonproliferative liver tissues of the CDAA-HF-T(+) and CDAA-HF-T(−) groups, and proliferative liver lesions of the CDAAHF-T(−) group. The following values are presented as the mean + SD. Control chow, 0.04 ± 0.02; CDAA-HF-T(+), 1.05 ± 0.60; CDAA-HF-T(−), 1.37 ± 0.29; CDAA-HF-T(+), 1.05 ± 0.60; CDAA-HF-T(−) in proliferative lesions, 4.49 ± 1.19 (c). The number of CK8/18-positive, putative hepatocellular preneoplastic lesions. The following values are presented as the mean + SD. One-cell positive lesion: control chow, 1.44 ± 1.42; CDAA-HF-T(+), 10.36 ± 7.26; CDAA-HF-T(−), 24.00 ± 12.52. Two-cell positive lesion: control chow, 0.56 ± 1.01; CDAA-HF-T(+), 0.45 ± 0.82; CDAA-HF-T(−), 3.10 ± 2.88. Three-cell positive lesion: control chow, 0.00 ± 0.00; CDAA-HF-T(+), 0.00 ± 0.00; CDAA-HF-T(−), 0.30 ± 0.95. d *Significantly different from the control value. Versus chow group; +Significantly different from the CDAA-HF-T(+) value

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