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Table 4 Accuracy and precision of ELP assay assessed during Q1-Q4 2019 by the CDC Lipids Standardization Program

From: The extended lipid panel assay: a clinically-deployed high-throughput nuclear magnetic resonance method for the simultaneous measurement of lipids and Apolipoprotein B

 

Total Cholesterol (mg/dL)

Triglycerides (mg/dL)

HDL Cholesterol (mg/dL)

Apolipoprotein B (mg/dL)

2019 Quarter/

Serum Pool

ELP

Valuea

CDC

Targetb

Biasc

%

CVd

%

ELP

Value

CDC

Target

Bias

%

CV

%

ELP

Value

CDC

Target

Bias

%

CV

%

ELP

Value

CDC

Target

Bias

%

CV

%

Q1/162

166.9

169.4

−1.5

1.6

88.3

88.5

−0.2

2.9

58.3

55.3

5.4

1.5

83.9

83.7

0.2

2.0

Q1/163

117.5

116.1

1.2

2.0

74.5

73.0

2.1

1.5

42.1

40.8

3.2

3.2

58.4

53.8

8.6

3.3

Q1/171

176.4

176.2

0.1

3.2

104.3

103.2

1.1

3.2

56.9

55.7

2.2

2.0

84.1

86.3

−2.5

2.5

Q2/171

173.4

176.2

−1.6

1.5

102.9

103.2

−0.3

1.9

56.6

55.7

1.6

2.9

83.4

86.3

−3.4

2.0

Q2/172

157.8

160.7

−1.8

3.0

79.8

78.8

1.3

3.4

51.6

51.8

−0.4

4.0

82.9

80.3

3.2

2.8

Q2/485

131.0

131.4

−0.3

3.6

107.9

106.8

1.0

1.8

37.3

34.8

7.2

2.0

72.4

70.3

3.0

2.8

Q3/171

178.8

176.2

1.5

1.8

105.5

103.2

2.2

2.9

57.9

55.7

3.9

1.4

87.0

86.3

0.8

2.6

Q3/172

162.6

160.7

1.2

1.9

82.4

78.8

4.6

2.2

53.0

51.8

2.3

1.7

84.8

80.8

5.0

2.2

Q3/173

184.0

187.9

−2.1

2.3

254.0

251.9

0.8

2.0

36.5

37.3

−2.1

3.3

106.9

104.8

2.0

1.5

Q4/174

152.8

152.6

0.1

1.8

85.4

88.0

−3.0

1.4

52.6

52.4

0.4

3.0

75.9

70.8

7.2

1.8

Q4/175

187.9

189.4

−0.8

1.4

164.5

165.0

−0.3

0.9

54.4

54.4

0.0

1.4

97.1

93.7

3.6

1.2

Q4/A100

182.4

183.5

−0.6

1.8

103.3

105.1

−1.7

1.3

57.3

55.5

3.2

1.8

90.1

87.0

3.6

3.3

Absolute Mean

  

1.1

2.2

  

1.6

2.1

  

2.7

2.4

  

3.6

2.3

  1. aELP values are the mean of 8 determinations from ELP testing conducted in duplicate at 3 week intervals. bTarget values of the CDC reference sera pools. cBias is the percent difference between ELP and CDC values. dPrecision of ELP measurement as given by the coefficient of variation (CV) of the 8 ELP determinations