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Table 2 Association between quartiles of low-density lipoprotein cholesterol and cardiovascular disease

From: Association between lipoprotein cholesterol and future cardiovascular disease and mortality in older adults: a Korean nationwide longitudinal study

  Event Duration (PYs) Incidence rate Crude Model 1 Model 2 Model 3
HR (95% CI) HR (95% CI) HR (95% CI) HR (95% CI)
β x 104 (P-value**) β x 104 (P-value**) β x 104 (P-value**) β x 104 (P-value**)
Cardiovascular event
 Ischemic heart disease 198 204025.6 0.970 0.90 (0.79–1.03) 0.90 (0.79–1.03) 0.95 (0.83–1.09) 0.95 (0.83–1.09)
     -4.170 (0.041) -2.874 (0.164) -2.874 (0.165) -1.159 (0.633)
 Ischemic brain disease 125 204025.6 0.613 0.80 (0.68–0.94) 0.83 (0.70–0.98) 0.83 (0.70–0.98) 0.84 (0.70–1.00)
     -4.019 (0.013) -3.450 (0.036) -3.454 (0.036) -3.389 (0.078)
 Total 323 204025.6 1.583 0.83 (0.75–0.92) 0.87 (0.79–0.97) 0.90 (0.81–1.01) 0.90 (0.81–1.01)
     -8.189 (0.002) -6.324 (0.017) -6.328 (0.016) -4.548 (0.142)
Cardiovascular death
 Ischemic heart disease 45 204058.7 0.221 0.88 (0.68–1.16) 0.99 (0.75–1.29) 0.99 (0.75–1.29) 1.13 (0.83–1.54)
     -0.708 (0.467) -0.017 (0.986) -0.022 (0.982) 0.961 (0.381)
 Ischemic brain disease 69 204058.7 0.338 0.90 (0.73–1.12) 0.93 (0.75–1.16) 0.93 (0.75–1.16) 0.95 (0.74–1.22)
     0.572 (0.543) 0.934 (0.327) 0.932 (0.329) 1.709 (0.103)
 Total 114 204058.7 0.559 0.89 (0.76–1.06) 0.95 (0.80–1.13) 0.95 (0.80–1.13) 1.01 (0.84–1.23)
     -1.617 (0.297) -0.655 (0.677) -0.663 (0.673) -0.701 (0.687)
  1. Model 1: age, sex
  2. Model 2: Model 1 + cigarette smoking
  3. Model 3: Model 2 + hypertension, diabetes mellitus, body mass index
  4. *Abbreviation: PY Person-year, HR Hazard ratio, CI Confidence interval
  5. Incidence rate is for the total participants.
  6. HR is for the 4th quartile compared to the 1st quartile.
  7. ** P-value is for β coefficient of multiple linear regression analysis.