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Table 2 Paraclinical characteristics of patients with clinical diagnosis of FH on the follow-up

From: Evaluation of cardiovascular risk factors in patients with familial hypercholesterolemia from the North-Eastern area of Romania

Characteristics

Patients with clinical diagnosis of FH

Baseline

12 months

24 months

P

TC mg/dL (median ± IQR)

315 ± 56

258 ± 37

237 ± 33

0.001*

LDL-C mg/dL (mean ±SD)

254.2 ± 53

185± 46

156 ± 40

0.001*

HDL-C mg/dL (median± IQR)

45.8 ±18

59 ± 15

68 ± 11

0.001*

TG mg/dL (mean ± SD)

174.4 ± 92

130± 49

119 ± 32

0.001*

Uric acid mg/dL (mean ± SD)

5.8 ± 1.22

5.3 ± 0.9

5.1 ± 1

0.001*

hsCRP mg/L (mean ± SD)

5.9 ± 2.29

5 ± 1.9

4.2 ± 1.7

0.001*

Glucose (median ± IQR)

97 ± 18

100 ± 15

97 ± 23

0.06

AST (median ± IQR)

25 ± 14

28 ± 15

28 ± 31

0.07

ALT (median ± IQR)

28 ± 20

33 ± 15

32 ± 15

0.2

ABI (mean ± SD)

0.96 ± 0.9

0.92 ± 0.6

0.91 ± 0.08

0.001*

cIMT mm (mean ± SD)

0.95 ± 0.3

0.91 ± 0.3

0.85 ± 0.3

0.001*

  1. Legend: TC Total cholesterol, LDL-C low density cholesterol lipoprotein, HDL-C high density cholesterol lipoprotein, TG triglycerides, hsCRP high-sensitivity C-reactive protein, AST aspartate transaminase, ALT alanine aminotransferase, ABI ankle-brachial index, cIMT carotid intima-media thickness
  2. *P< 0.05