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Table 2 Paraclinical characteristics of patients with clinical diagnosis of FH on the follow-up

From: Evaluation of cardiovascular risk factors in patients with familial hypercholesterolemia from the North-Eastern area of Romania

Characteristics Patients with clinical diagnosis of FH
Baseline 12 months 24 months P
TC mg/dL (median ± IQR) 315 ± 56 258 ± 37 237 ± 33 0.001*
LDL-C mg/dL (mean ±SD) 254.2 ± 53 185± 46 156 ± 40 0.001*
HDL-C mg/dL (median± IQR) 45.8 ±18 59 ± 15 68 ± 11 0.001*
TG mg/dL (mean ± SD) 174.4 ± 92 130± 49 119 ± 32 0.001*
Uric acid mg/dL (mean ± SD) 5.8 ± 1.22 5.3 ± 0.9 5.1 ± 1 0.001*
hsCRP mg/L (mean ± SD) 5.9 ± 2.29 5 ± 1.9 4.2 ± 1.7 0.001*
Glucose (median ± IQR) 97 ± 18 100 ± 15 97 ± 23 0.06
AST (median ± IQR) 25 ± 14 28 ± 15 28 ± 31 0.07
ALT (median ± IQR) 28 ± 20 33 ± 15 32 ± 15 0.2
ABI (mean ± SD) 0.96 ± 0.9 0.92 ± 0.6 0.91 ± 0.08 0.001*
cIMT mm (mean ± SD) 0.95 ± 0.3 0.91 ± 0.3 0.85 ± 0.3 0.001*
  1. Legend: TC Total cholesterol, LDL-C low density cholesterol lipoprotein, HDL-C high density cholesterol lipoprotein, TG triglycerides, hsCRP high-sensitivity C-reactive protein, AST aspartate transaminase, ALT alanine aminotransferase, ABI ankle-brachial index, cIMT carotid intima-media thickness
  2. *P< 0.05