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Table 2 The association between resveratrol intake on lipid profiles and liver enzymes using subgroup analysis

From: The effects of resveratrol on lipid profiles and liver enzymes in patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials

Variables

Number of WMD included

Subgroups

Pooled WMD (random effect)

95% CI

I2 (%)

Overall I2 (%)

Triglycerides

 

32

Overall

-5.84

−12.68, 1.00

66.8

66.8

Type of intervention

6

Resveratrol plus other nutrients or drugs

−8.81

−13.67, − 3.96

0.0

26

Resveratrol

−5.06

− 14.41, 4.29

71.8

Dosage of resveratrol (mg/day)

10

≥ 500 mg resveratrol

1.43

−7.84, 10.69

0.0

22

<  500 mg resveratrol

−8.07

−16.20, 0.05

74.1

Duration of study (week)

14

<  12 weeks

−4.93

−19.17, 9.31

70.8

18

≥ 12 weeks

−5.40

−11.53, 0.74

40.5

Type of disease

8

Overweight or obese

1.44

−13.46, 16.34

0.0

16

Other

−5.41

−15.72, 4.91

74.1

8

T2DM

−8.06

−21.30, 5.17

58.4

Total cholesterol

 

28

Overall

−7.65

−12.93, − 2.37

83.4

83.4

Type of intervention

5

Resveratrol plus other nutrients or drugs

−18.10

−27.80, −8.39

80.5

23

Resveratrol

−4.02

−10.53, 2.49

84.4

Dosage of resveratrol (mg/day)

9

≥ 500 mg resveratrol

−2.47

−13.62, 8.67

64.3

19

<  500 mg resveratrol

−10.07

−15.81, −4.33

84.2

Duration of study (week)

15

<  12 weeks

−8.61

−16.64, −0.57

78.5

13

≥ 12 weeks

−5.29

−14.06, 3.49

87.6

Type of disease

5

Overweight or obese

1.93

−5.65, 9.50

0.0

15

Other

−8.32

−16.28, −0.36

83.8

8

T2DM

−9.68

−21.12, 1.76

83.4

LDL-cholesterol

 

27

Overall

−2.90

−10.88, 5.09

96.0

96.0

Type of intervention

5

Resveratrol plus other nutrients or drugs

−17.61

−29.20, −6.01

92.2

22

Resveratrol

0.84

−8.72, 10.39

96.1

Dosage of resveratrol (mg/day)

10

≥ 500 mg resveratrol

5.47

−9.90, 20.84

93.8

17

<  500 mg resveratrol

−9.89

−15.45, −4.33

86.2

Duration of study (week)

14

<  12 weeks

−7.38

−15.47, 0.71

85.9

13

≥ 12 weeks

0.59

−12.65, 13.84

97.6

Type of disease

3

Overweight or obese

3.47

−6.35, 13.29

0.0

16

Other

−2.94

−14.71, 8.82

97.0

8

T2DM

−5.10

−16.01, 5.80

88.1

HDL-cholesterol

 

29

Overall

0.49

−0.80, 1.78

74.0

74.0

Type of intervention

5

Resveratrol plus other nutrients or drugs

2.31

0.63, 3.98

44.4

24

Resveratrol

−0.02

−1.52, 1.49

73.4

Dosage of resveratrol (mg/day)

10

≥ 500 mg resveratrol

0.55

−2.21, 3.32

78.2

19

<  500 mg resveratrol

0.31

−1.11, 1.72

69.1

Duration of study (week)

15

<  12 weeks

0.26

−1.66, 2.18

72.1

14

≥ 12 weeks

0.79

− 0.92, 2.50

71.1

Type of disease

4

Overweight or obese

−0.46

−2.51, 1.59

0.0

16

Other

0.61

−1.55, 2.76

69.3

9

T2DM

0.63

−1.43, 2.70

74.3

ALT

 

13

Overall

−0.14

−3.69, 3.41

79.6

79.6

Type of intervention

2

Resveratrol plus other nutrients or drugs

2.00

−1.56, 5.56

25.2

11

Resveratrol

−0.74

−4.88, 3.41

78.9

Dosage of resveratrol (mg/day)

9

≥ 500 mg resveratrol

−1.77

−6.37, 2.84

80.8

4

<  500 mg resveratrol

2.19

−0.51, 4.89

0.0

Duration of study (week)

7

<  12 weeks

1.52

−0.39, 3.43

0.0

11

≥ 12 weeks

−2.01

−8.09, 4.08

78.2

Type of disease

2

Overweight or obese

1.34

−5.36, 8.04

0.0

7

Other

−1.76

−7.00, 3.48

83.8

4

T2DM

1.75

−1.43, 4.92

27.3

AST

 

10

Overall

−0.34

−2.94, 2.27

88.0

88.0

Type of intervention

2

Resveratrol plus other nutrients or drugs

−2.22

−11.24, 6.79

93.7

8

Resveratrol

0.18

−2.70, 3.05

87.5

Dosage of resveratrol (mg/day)

6

≥ 500 mg resveratrol

0.28

−3.78, 4.35

84.1

4

<  500 mg resveratrol

−0.83

−4.42, 2.76

87.5

Duration of study (week)

7

<  12 weeks

0.96

−1.92, 3.84

79.1

3

≥ 12 weeks

−3.16

−6.43, 0.12

76.1

Type of disease

1

Overweight or obese

−0.12

−3.54, 3.30

–

5

Other

−2.61

−6.29, 1.06

83.6

4

T2DM

1.23

0.30, 2.17

0.0

GGT

 

5

Overall

1.76

0.58, 2.94

20.1

20.1

Type of intervention

–

Resveratrol plus other nutrients or drugs

–

–

–

5

Resveratrol

1.76

0.58, 2.94

20.1

Dosage of resveratrol (mg/day)

3

≥ 500 mg resveratrol

1.05

−1.31, 3.40

55.9

2

<  500 mg resveratrol

2.00

0.63, 3.36

0.0

Duration of study (week)

2

<  12 weeks

2.01

0.71, 3.32

0.0

3

≥ 12 weeks

0.60

−2.17, 3.37

52.2

Type of disease

1

Overweight or obese

1.74

−8.78, 12.26

–

2

Other

0.52

−2.35, 3.39

75.8

2

T2DM

2.00

0.71, 3.32

0.0

  1. ALT Alanine aminotransferase, AST Aspartate aminotransferase, GGT Gamma-glutamyl transferase