Variables | Number of WMD included | Subgroups | Pooled WMD (random effect) | 95% CI | I2 (%) | Overall I2 (%) | |
---|---|---|---|---|---|---|---|
Triglycerides |  | 32 | Overall | -5.84 | −12.68, 1.00 | 66.8 | 66.8 |
Type of intervention | 6 | Resveratrol plus other nutrients or drugs | −8.81 | −13.67, − 3.96 | 0.0 | ||
26 | Resveratrol | −5.06 | − 14.41, 4.29 | 71.8 | |||
Dosage of resveratrol (mg/day) | 10 | ≥ 500 mg resveratrol | 1.43 | −7.84, 10.69 | 0.0 | ||
22 | <  500 mg resveratrol | −8.07 | −16.20, 0.05 | 74.1 | |||
Duration of study (week) | 14 | <  12 weeks | −4.93 | −19.17, 9.31 | 70.8 | ||
18 | ≥ 12 weeks | −5.40 | −11.53, 0.74 | 40.5 | |||
Type of disease | 8 | Overweight or obese | 1.44 | −13.46, 16.34 | 0.0 | ||
16 | Other | −5.41 | −15.72, 4.91 | 74.1 | |||
8 | T2DM | −8.06 | −21.30, 5.17 | 58.4 | |||
Total cholesterol |  | 28 | Overall | −7.65 | −12.93, − 2.37 | 83.4 | 83.4 |
Type of intervention | 5 | Resveratrol plus other nutrients or drugs | −18.10 | −27.80, −8.39 | 80.5 | ||
23 | Resveratrol | −4.02 | −10.53, 2.49 | 84.4 | |||
Dosage of resveratrol (mg/day) | 9 | ≥ 500 mg resveratrol | −2.47 | −13.62, 8.67 | 64.3 | ||
19 | <  500 mg resveratrol | −10.07 | −15.81, −4.33 | 84.2 | |||
Duration of study (week) | 15 | <  12 weeks | −8.61 | −16.64, −0.57 | 78.5 | ||
13 | ≥ 12 weeks | −5.29 | −14.06, 3.49 | 87.6 | |||
Type of disease | 5 | Overweight or obese | 1.93 | −5.65, 9.50 | 0.0 | ||
15 | Other | −8.32 | −16.28, −0.36 | 83.8 | |||
8 | T2DM | −9.68 | −21.12, 1.76 | 83.4 | |||
LDL-cholesterol |  | 27 | Overall | −2.90 | −10.88, 5.09 | 96.0 | 96.0 |
Type of intervention | 5 | Resveratrol plus other nutrients or drugs | −17.61 | −29.20, −6.01 | 92.2 | ||
22 | Resveratrol | 0.84 | −8.72, 10.39 | 96.1 | |||
Dosage of resveratrol (mg/day) | 10 | ≥ 500 mg resveratrol | 5.47 | −9.90, 20.84 | 93.8 | ||
17 | <  500 mg resveratrol | −9.89 | −15.45, −4.33 | 86.2 | |||
Duration of study (week) | 14 | <  12 weeks | −7.38 | −15.47, 0.71 | 85.9 | ||
13 | ≥ 12 weeks | 0.59 | −12.65, 13.84 | 97.6 | |||
Type of disease | 3 | Overweight or obese | 3.47 | −6.35, 13.29 | 0.0 | ||
16 | Other | −2.94 | −14.71, 8.82 | 97.0 | |||
8 | T2DM | −5.10 | −16.01, 5.80 | 88.1 | |||
HDL-cholesterol |  | 29 | Overall | 0.49 | −0.80, 1.78 | 74.0 | 74.0 |
Type of intervention | 5 | Resveratrol plus other nutrients or drugs | 2.31 | 0.63, 3.98 | 44.4 | ||
24 | Resveratrol | −0.02 | −1.52, 1.49 | 73.4 | |||
Dosage of resveratrol (mg/day) | 10 | ≥ 500 mg resveratrol | 0.55 | −2.21, 3.32 | 78.2 | ||
19 | <  500 mg resveratrol | 0.31 | −1.11, 1.72 | 69.1 | |||
Duration of study (week) | 15 | <  12 weeks | 0.26 | −1.66, 2.18 | 72.1 | ||
14 | ≥ 12 weeks | 0.79 | − 0.92, 2.50 | 71.1 | |||
Type of disease | 4 | Overweight or obese | −0.46 | −2.51, 1.59 | 0.0 | ||
16 | Other | 0.61 | −1.55, 2.76 | 69.3 | |||
9 | T2DM | 0.63 | −1.43, 2.70 | 74.3 | |||
ALT |  | 13 | Overall | −0.14 | −3.69, 3.41 | 79.6 | 79.6 |
Type of intervention | 2 | Resveratrol plus other nutrients or drugs | 2.00 | −1.56, 5.56 | 25.2 | ||
11 | Resveratrol | −0.74 | −4.88, 3.41 | 78.9 | |||
Dosage of resveratrol (mg/day) | 9 | ≥ 500 mg resveratrol | −1.77 | −6.37, 2.84 | 80.8 | ||
4 | <  500 mg resveratrol | 2.19 | −0.51, 4.89 | 0.0 | |||
Duration of study (week) | 7 | <  12 weeks | 1.52 | −0.39, 3.43 | 0.0 | ||
11 | ≥ 12 weeks | −2.01 | −8.09, 4.08 | 78.2 | |||
Type of disease | 2 | Overweight or obese | 1.34 | −5.36, 8.04 | 0.0 | ||
7 | Other | −1.76 | −7.00, 3.48 | 83.8 | |||
4 | T2DM | 1.75 | −1.43, 4.92 | 27.3 | |||
AST |  | 10 | Overall | −0.34 | −2.94, 2.27 | 88.0 | 88.0 |
Type of intervention | 2 | Resveratrol plus other nutrients or drugs | −2.22 | −11.24, 6.79 | 93.7 | ||
8 | Resveratrol | 0.18 | −2.70, 3.05 | 87.5 | |||
Dosage of resveratrol (mg/day) | 6 | ≥ 500 mg resveratrol | 0.28 | −3.78, 4.35 | 84.1 | ||
4 | <  500 mg resveratrol | −0.83 | −4.42, 2.76 | 87.5 | |||
Duration of study (week) | 7 | <  12 weeks | 0.96 | −1.92, 3.84 | 79.1 | ||
3 | ≥ 12 weeks | −3.16 | −6.43, 0.12 | 76.1 | |||
Type of disease | 1 | Overweight or obese | −0.12 | −3.54, 3.30 | – | ||
5 | Other | −2.61 | −6.29, 1.06 | 83.6 | |||
4 | T2DM | 1.23 | 0.30, 2.17 | 0.0 | |||
GGT | Â | 5 | Overall | 1.76 | 0.58, 2.94 | 20.1 | 20.1 |
Type of intervention | – | Resveratrol plus other nutrients or drugs | – | – | – | ||
5 | Resveratrol | 1.76 | 0.58, 2.94 | 20.1 | |||
Dosage of resveratrol (mg/day) | 3 | ≥ 500 mg resveratrol | 1.05 | −1.31, 3.40 | 55.9 | ||
2 | <  500 mg resveratrol | 2.00 | 0.63, 3.36 | 0.0 | |||
Duration of study (week) | 2 | <  12 weeks | 2.01 | 0.71, 3.32 | 0.0 | ||
3 | ≥ 12 weeks | 0.60 | −2.17, 3.37 | 52.2 | |||
Type of disease | 1 | Overweight or obese | 1.74 | −8.78, 12.26 | – | ||
2 | Other | 0.52 | −2.35, 3.39 | 75.8 | |||
2 | T2DM | 2.00 | 0.71, 3.32 | 0.0 |