Skip to main content

Table 2 The association between resveratrol intake on lipid profiles and liver enzymes using subgroup analysis

From: The effects of resveratrol on lipid profiles and liver enzymes in patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials

VariablesNumber of WMD includedSubgroupsPooled WMD (random effect)95% CII2 (%)Overall I2 (%)
Triglycerides 32Overall-5.84−12.68, 1.0066.866.8
Type of intervention6Resveratrol plus other nutrients or drugs−8.81−13.67, − 3.960.0
26Resveratrol−5.06− 14.41, 4.2971.8
Dosage of resveratrol (mg/day)10≥ 500 mg resveratrol1.43−7.84, 10.690.0
22<  500 mg resveratrol−8.07−16.20, 0.0574.1
Duration of study (week)14<  12 weeks−4.93−19.17, 9.3170.8
18≥ 12 weeks−5.40−11.53, 0.7440.5
Type of disease8Overweight or obese1.44−13.46, 16.340.0
16Other−5.41−15.72, 4.9174.1
8T2DM−8.06−21.30, 5.1758.4
Total cholesterol 28Overall−7.65−12.93, − 2.3783.483.4
Type of intervention5Resveratrol plus other nutrients or drugs−18.10−27.80, −8.3980.5
23Resveratrol−4.02−10.53, 2.4984.4
Dosage of resveratrol (mg/day)9≥ 500 mg resveratrol−2.47−13.62, 8.6764.3
19<  500 mg resveratrol−10.07−15.81, −4.3384.2
Duration of study (week)15<  12 weeks−8.61−16.64, −0.5778.5
13≥ 12 weeks−5.29−14.06, 3.4987.6
Type of disease5Overweight or obese1.93−5.65, 9.500.0
15Other−8.32−16.28, −0.3683.8
8T2DM−9.68−21.12, 1.7683.4
LDL-cholesterol 27Overall−2.90−10.88, 5.0996.096.0
Type of intervention5Resveratrol plus other nutrients or drugs−17.61−29.20, −6.0192.2
22Resveratrol0.84−8.72, 10.3996.1
Dosage of resveratrol (mg/day)10≥ 500 mg resveratrol5.47−9.90, 20.8493.8
17<  500 mg resveratrol−9.89−15.45, −4.3386.2
Duration of study (week)14<  12 weeks−7.38−15.47, 0.7185.9
13≥ 12 weeks0.59−12.65, 13.8497.6
Type of disease3Overweight or obese3.47−6.35, 13.290.0
16Other−2.94−14.71, 8.8297.0
8T2DM−5.10−16.01, 5.8088.1
HDL-cholesterol 29Overall0.49−0.80, 1.7874.074.0
Type of intervention5Resveratrol plus other nutrients or drugs2.310.63, 3.9844.4
24Resveratrol−0.02−1.52, 1.4973.4
Dosage of resveratrol (mg/day)10≥ 500 mg resveratrol0.55−2.21, 3.3278.2
19<  500 mg resveratrol0.31−1.11, 1.7269.1
Duration of study (week)15<  12 weeks0.26−1.66, 2.1872.1
14≥ 12 weeks0.79− 0.92, 2.5071.1
Type of disease4Overweight or obese−0.46−2.51, 1.590.0
16Other0.61−1.55, 2.7669.3
9T2DM0.63−1.43, 2.7074.3
ALT 13Overall−0.14−3.69, 3.4179.679.6
Type of intervention2Resveratrol plus other nutrients or drugs2.00−1.56, 5.5625.2
11Resveratrol−0.74−4.88, 3.4178.9
Dosage of resveratrol (mg/day)9≥ 500 mg resveratrol−1.77−6.37, 2.8480.8
4<  500 mg resveratrol2.19−0.51, 4.890.0
Duration of study (week)7<  12 weeks1.52−0.39, 3.430.0
11≥ 12 weeks−2.01−8.09, 4.0878.2
Type of disease2Overweight or obese1.34−5.36, 8.040.0
7Other−1.76−7.00, 3.4883.8
4T2DM1.75−1.43, 4.9227.3
AST 10Overall−0.34−2.94, 2.2788.088.0
Type of intervention2Resveratrol plus other nutrients or drugs−2.22−11.24, 6.7993.7
8Resveratrol0.18−2.70, 3.0587.5
Dosage of resveratrol (mg/day)6≥ 500 mg resveratrol0.28−3.78, 4.3584.1
4<  500 mg resveratrol−0.83−4.42, 2.7687.5
Duration of study (week)7<  12 weeks0.96−1.92, 3.8479.1
3≥ 12 weeks−3.16−6.43, 0.1276.1
Type of disease1Overweight or obese−0.12−3.54, 3.30
5Other−2.61−6.29, 1.0683.6
4T2DM1.230.30, 2.170.0
GGT 5Overall1.760.58, 2.9420.120.1
Type of interventionResveratrol plus other nutrients or drugs
5Resveratrol1.760.58, 2.9420.1
Dosage of resveratrol (mg/day)3≥ 500 mg resveratrol1.05−1.31, 3.4055.9
2<  500 mg resveratrol2.000.63, 3.360.0
Duration of study (week)2<  12 weeks2.010.71, 3.320.0
3≥ 12 weeks0.60−2.17, 3.3752.2
Type of disease1Overweight or obese1.74−8.78, 12.26
2Other0.52−2.35, 3.3975.8
2T2DM2.000.71, 3.320.0
  1. ALT Alanine aminotransferase, AST Aspartate aminotransferase, GGT Gamma-glutamyl transferase