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Fig. 4 | Lipids in Health and Disease

Fig. 4

From: Proprotein convertase subtilisin/kexin type 9 (PCSK9) levels are not associated with severity of liver disease and are inversely related to cholesterol in a cohort of thirty eight patients with liver cirrhosis

Fig. 4

PCSK9 and LDL-receptor protein in the liver of patients with chronic liver diseases. PCSK9, LDL-receptor, alpha-SMA and GAPDH protein in the liver of patients with a chronic HBV infection, b chronic HCV infection and c non-viral liver disease. The respective fibrosis stages are listed below the figure panels. LC is the loading control and was used for normalization of the different immunoblots. d Correlation of hepatic PCSK9 protein with fibrosis stage. e PCSK9 in the liver of patients with fibrosis stage 0 to 3 (non-cirrhosis) and in patients with liver cirrhosis (fibrosis stage 4). f Correlation of hepatic PCSK9 and LDL-receptor protein. g PCSK9, LDL-receptor, CRP and GAPDH protein in the liver of patients with chronic HCV infection (patient number 1, 3, 5, 7, 9) and non-viral disease (patient number 2, 4, 6, 8, 10). The respective fibrosis stages are listed below the figure. h Quantification of PCSK9 and i LDL-receptor in the liver of patients with chronic HCV infection and non-viral disease. Coomassie stained membranes are shown to further confirm equal loading of the immunoblots. ** P < 0.01, *** P < 0.001

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