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Table 1 Patient demographics and laboratory parameters (C-reactive protein, CRP; alanine aminotransferase, ALT; aspartate aminotransferase, AST). Median values and range of the values are shown. Superscript digits were added when the respective information was not available for the whole study group and correspond to the number of patients where these data were documented. Not applicable, na; not determined, nd; *** P < 0.001 for comparison of serum parameters from cirrhotic and non-cirrhotic patients

From: Proprotein convertase subtilisin/kexin type 9 (PCSK9) levels are not associated with severity of liver disease and are inversely related to cholesterol in a cohort of thirty eight patients with liver cirrhosis

  Cirrhosis Patients
Plasma
Cirrhosis Patients
Serum
Non-cirrhosis Patients
Serum
Number 38 26 55
Sex (female/male) 9/29 5/21 23/32
Age (years) 53 (26–81) 49 (40–81) 58 (21–80)
Child-Pugh score A/B/C/nd 10/13/15/0 8/7/7/4 na
MELD score 9 (6–21) 8 (6–21) 22 na
Ascites: no / little / modest / massive /nd 4/11/4/19/0 6/9/2/8/1 na
Variceal size: no / small / large / nd 6/7/25/0 5/4/16/1 na
C-reactive protein (mg/L) 14.4 (1.0–53.5) 35 13.9 (2.0–46.7) 20 nd
Fibrinogen (mg/dL) 263 (114–520) 37 349 (151–515) 22 nd
Antithrombin 3 (%) 63.7 (23.6–100.0) 34 65 (23.6–92.8) 21 nd
Factor V (%) 59 (17–137) 25 61 (17–127) 20 nd
ALT (U/l) 38 (4–108) 38 (7–108) 32 (16–288) 54
AST (U/l) 30.0 (2–84) 29 (2–73) 24 (12–256) 54
Albumin (g/L) 31.2 (1.6–47.0) 31.5 (1.6–4.1) 46.8 (31.6–55.6) ***
Bilirubin (mg/dL) 1.2 (0.3–8.2) 1.1 (0.4–3.7) 0.5 (0.2–2.8) 53 ***
Quick prothrombin time (%) 72 (28–100) 76 (44–100) 22 nd
Creatinine (mg/dL) 1.1 (0.5–4.5) 1.0 (0.6–4.5) 22 nd
LDL (mg/dL)  60 (6-128) 35 (17–81) 112 (44–340)52 ***
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