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Table 1 Clinical and biochemical characteristics of study subjects

From: Familial hypertriglyceridemia: an entity with distinguishable features from other causes of hypertriglyceridemia

Variable

Normal Triglycerides

CHTG

FHTG

P value

ALL

P value*

FHTG vs CHTG

Sample size

609

728

84

  

Sex (% females) a

69.2

51.1

24.4

< 0.001

< 0.001

Age (years)

54 [48–63]

53 [48–60]

43 [37–47.8]

< 0.001

< 0.001

BMI (kg/m2)

27 [24.7–30]b

28.6 [25.9–31.6]

28.9 [26.1–32.1]

< 0.001

0.718

Waist circumference (cm)

90.8 [84.5–98]b

95.4 [89.5–103]

96 [88–100]

< 0.001

0.581

Triglycerides (mg/ dL)

113 [88.57–130]

270 [228–331.25]

916.46 [293.24–1435.44]c

< 0.001

< 0.001

Cholesterol (mg/ dL)

195 [168.52–218.31]

217 [190–243]

191.02 [163–250.87]c

< 0.001

0.027

HDL-C (mg/ dL)

47 [42–55]

38 [32–44]

30.64 [24.89–37.34]

< 0.001

< 0.001

Non- HDL-C (mg/ dL)

145 [121–168]

176 [154–201]

159 [130–216] c

< 0.001

0.288

Apo B (mg/ dL)

103 [86–118]

126 [108–143]

91.8 [82–97.6]

< 0.001

< 0.001

Glucose (mg/ dL)

90 [83–108]b

94 [85–148.25]

99 [90.5–119]

< 0.001

0.361

Insulin (μU/L)

8.3 [5.6–12]b

10.35 [7.57–15.7]

13.3 [7.9–18.8]

< 0.001

0.036

HOMA2 B%

106.2 [81.3–139.4]

119.85 [92.6–159.7]d

102.2 [65.8–154.4]

< 0.001

0.002

HOMA IR

1.06[0.72–1.56]b

1.37 [1.0–2.06]

1.79 [1.17–2.28]

< 0.001

0.004

T2D (%)a

31.7

39.8

25.6

< 0.001

0.010

AP (%)

–

–

20%

< 0.001

< 0.001

  1. Median [25th percentile-75th percentile] or percentages are shown. AP: Acute pancreatitis
  2. a Chi square/Fisher exact test
  3. Kruskall Wallis test for metabolic traits adjusted for age, BMI, triglycerides levels and sex;
  4. b post hoc P < 0.01 by Dunn test: Normal triglycerides subjects different among the other groups
  5. c post hoc P < 0.01 by Dunn test: FHTG subjects different only from CHTG subjects
  6. d post hoc P < 0.01 by Dunn test: CHTG subjects different among the other groups
  7. *U-Mann Whitney test