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Fig. 11 | Lipids in Health and Disease

Fig. 11

From: Identification of lipidomic profiles associated with drug-resistant prostate cancer cells

Fig. 11

a Alterations in lipin genes LPIN1, LPIN2 and LPIN3 within four types of prostate cancer from sixteen studies. Amplification is the major alteration in all types, excluding general prostate cancer. b Overall survivability in prostate cancer patients with (red) or without (blue) lipin gene alteration. There are 28 samples with alterations in LPIN1, 37 samples from 30 patients with alterations in LPIN2 and 27 samples out of 26 patients with LPIN3 alterations. c mRNA expression, accurate transcript quantification from RNA-Seq data (RSEM) as a function of putative copy-number alterations in mutation type. There are 10,712 samples from 32 studies on the horizontal axis, 6961 samples from 16 studies on the vertical axis and 6909 samples from 16 studies at the intersection of the two axes. The figures were generated from cBioPortal for Cancer Genomics. d Variation in expression levels of lipin genes were observed in patients with (red) and without (green) prostate cancer. The method for differential analysis was a one-way ANOVA, using disease state (Tumor or Normal) as variable for calculating differential expression. Pair-wise gene expression correlations, using the Pearson method, of the lipin genes were analyzed based on TCGA and GTEx databases. The non-log scale for calculation and use the log-scale axis for visualization. The figures were generated from GEPIA 2. PRAD prostate adenocarcinoma, T tumor, N normal, TPM transcripts per million

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