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Fig. 3 | Lipids in Health and Disease

Fig. 3

From: Identification of lipidomic profiles associated with drug-resistant prostate cancer cells

Fig. 3

Alterations of phospholipid and acyl glycerol classes were observed in non-cancerous prostate cells (blue), hormone-sensitive (dark red), castration-resistant (CR) (green), and Docetaxel resistant (DR) (red) prostate cancer cells. LC-ESI-MS/MS analysis of these classes in comparison to the Kennedy Pathway demonstrates alterations of the lipid abundance within progressing prostate cancer cells. The enzymes mediating the remodeling are shown in blue along the arrows. CHPT1 Cholinephosphotransferase 1, CEPT1 Choline/ethanolaminephosphotransferase 1, DAG diacylglycerol, DGAT diacylglycerol acyltransferase, PA phosphatidic acid, PAP phosphatidic acid phosphatase, PC phosphatidylcholine, PLD Phospholipase D, PE phosphatidylethanolamine, PEMT Phosphatidylethanolamine-N-methyltransferase, PG phosphatidylglycerol, PGP phosphatidylglycerol phosphatase, PS phosphatidylserine, PSS1/ PSS2 phosphatidylserine synthase, PISD Phosphatidylserine decarboxylases, TAG triacylglycerol

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