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Table 1 Binding constants (KD) determined for 5 different phospholipid forms against 504B3

From: Lysophosphatidic acid (LPA)-antibody (504B3) engagement detected by interferometry identifies off-target binding

Lysophospholipid KD from FSA ± SD (95% CI) Bmax (95% CI) R2
18:1 LPA 3.7 ± 2.8 nM (2.1 to 9.0) 0.17 (0.14 to 0.25) 0.83
18:1 PA 3.3 ± 2.7 nM (1.5 to 6.4) 0.15 (0.12 to 0.17) 0.81
18:1 LPC 8.5 ± 2.6 nM (5.3 to 13.5) 0.14 (0.12 to 0.16) 0.90
16:0 LPA > 30 nM (undetermineda) 0.39 (undetermineda) 0.94
18:1 S1P ~ 0
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