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Table 2 Hazard ratios for NAFLD events by quintiles of serum lipoproteins and LDL/HDL cholesterol ratio

From: LDL/HDL cholesterol ratio is associated with new-onset NAFLD in Chinese non-obese people with normal lipids: a 5-year longitudinal cohort study

 

HR (95%CI)

Multivariable Analysis

Q1

Q2

Q3

Q4

Q5

P-trend

HDL cholesterol (mmol/l)

 Crude Model

0.25 (0.19, 0.33)

Ref

0.92 (0.77, 1.10)

0.71 (0.58, 0.86)

0.51 (0.41, 0.63)

0.32 (0.25, 0.41)

< 0.001

 Model I

0.26 (0.20, 0.33)

Ref

0.92 (0.77, 1.10)

0.71 (0.58, 0.87)

0.51 (0.41, 0.64)

0.32 (0.25, 0.41)

< 0.001

 Model II

0.59 (0.45, 0.77)

Ref

1.05 (0.88, 1.26)

0.95 (0.78, 1.17)

0.85 (0.68, 1.06)

0.60 (0.46, 0.79)

< 0.001

 Model III

0.59 (0.44, 0.78)

Ref

1.04 (0.86, 1.25)

0.91 (0.74, 1.11)

0.83 (0.66, 1.04)

0.61 (0.47, 0.80)

< 0.001

 Model IV

0.57 (0.42, 0.75)

Ref

0.98 (0.82, 1.18)

0.84 (0.69, 1.04)

0.80 (0.64, 1.01)

0.61 (0.46, 0.79)

< 0.001

LDL cholesterol (mmol/l)

 Crude Model

3.24 (2.70, 3.88)

Ref

1.12 (0.85, 1.49)

1.45 (1.12, 1.89)

1.97 (1.53, 2.52)

3.37 (2.67, 4.26)

< 0.001

 Model I

3.21 (2.68, 3.85)

Ref

1.12 (0.85, 1.49)

1.45 (1.11, 1.88)

1.96 (1.53, 2.51)

3.34 (2.64, 4.22)

< 0.001

 Model II

3.18 (2.40, 4.21)

Ref

1.26 (0.93, 1.69)

1.48 (1.09, 2.02)

2.00 (1.45, 2.76)

3.10 (2.17, 4.41)

< 0.001

 Model III

2.72 (2.03, 3.63)

Ref

1.25 (0.92, 1.70)

1.40 (1.02, 1.92)

1.80 (1.29, 2.50)

2.65 (1.84, 3.82)

< 0.001

 Model IV

2.60 (1.95, 3.48)

Ref

1.22 (0.90, 3.48)

1.37 (0.99, 1.88)

1.70 (1.22, 2.37)

2.50 (1.74, 3.60)

< 0.001

LDL/HDL cholesterol ratio

 Crude Model

3.42 (2.93, 3.99)

Ref

1.92 (1.40, 2.63)

2.47 (1.82, 3.35)

3.05 (2.27, 4.10)

5.35 (4.05, 7.07)

< 0.001

 Model I

3.38 (2.90, 3.95)

Ref

1.92 (1.40, 2.64)

2.47 (1.82, 3.35)

3.05 (2.27, 4.10)

5.32 (4.02, 7.03)

< 0.001

 Model II

1.72 (1.44, 2.06)

Ref

1.63 (1.18, 2.24)

1.89 (1.39, 2.58)

1.87 (1.38, 2.53)

2.43 (1.80, 3.28)

< 0.001

 Model III

1.64 (1.37, 1.97)

Ref

1.70 (1.23, 2.35)

1.83 (1.34, 2.51)

1.89 (1.39, 2.56)

2.41 (1.77, 3.27)

< 0.001

 Model IV

1.66 (1.38, 1.99)

Ref

1.68 (1.21, 2.33)

1.78 (1.30, 2.44)

1.86 (1.36, 2.55)

2.40 (1.76, 3.27)

< 0.001

  1. Crude model adjusted for none; Model I adjusted for gender and age; Model II adjusted for TC, TG and BMI; Model III adjusted for gender, age, ALP, GGT, ALT, AST, ALB, GLB, DBIL, CR, UA, FPG, TC, TG, height, BMI, SBP and DBP; Model IV adjusted for Model III and TP, TB, BUN
  2. Abbreviations: NAFLD nonalcoholic fatty liver disease, CI confidence interval, HR hazard ratios; other abbreviations as in Table 1