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Fig. 4 | Lipids in Health and Disease

Fig. 4

From: TWIST2 and the PPAR signaling pathway are important in the progression of nonalcoholic steatohepatitis

Fig. 4

PPAR signaling pathway genes were enriched significantly in LO-2 cells by OA treatment (50 μg/mL, 48 h). a KEGG pathway analysis based on the KEGG website. The top 10 upregulated pathways of differentially expressed (DE) genes are shown here. b The top 10 downregulated pathways of DE genes based on the KEGG website shown here. c The mRNA levels of four genes in the PPAR signaling pathway, namely, ACSL4, ANGPTL4, CPT1A, and PLIN4, showed increased transcription based on RT-PCR. d A schematic model of the PPARγ pathway in lipid metabolism and adipocyte differentiation was drawn, indicating the mechanism of the PPAR signaling pathway in NAFLD

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