Fig. 4
PPAR signaling pathway genes were enriched significantly in LO-2 cells by OA treatment (50āĪ¼g/mL, 48āh). a KEGG pathway analysis based on the KEGG website. The top 10 upregulated pathways of differentially expressed (DE) genes are shown here. b The top 10 downregulated pathways of DE genes based on the KEGG website shown here. c The mRNA levels of four genes in the PPAR signaling pathway, namely, ACSL4, ANGPTL4, CPT1A, and PLIN4, showed increased transcription based on RT-PCR. d A schematic model of the PPARĪ³ pathway in lipid metabolism and adipocyte differentiation was drawn, indicating the mechanism of the PPAR signaling pathway in NAFLD