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Table 3 Details on the top 20 upregulated and downregulated genes under oleic acid treatment as determined by RNA sequencing. The top 20 upregulated genes are listed, including, among others, ASNS-209, APLP2–202, and PSAP-201. The top 20 downregulated genes included, among others, APLP2–201, DDX27–206, and CARD10–203. All the genes were significantly differentially expressed (P < 0.05)

From: TWIST2 and the PPAR signaling pathway are important in the progression of nonalcoholic steatohepatitis

Gene name Transcript name log2(fold change) Fold change P value Gene name Transcript name log2(fold change) Fold change P value
Upregulated genes Downregulated genes
ASNS ASNS-209 4.9946 31.8794 0.0000 APLP2 APLP2–201 −3.2019 0.1087 0.0001
APLP2 APLP2–202 4.0958 17.0984 0.0070 DDX27 DDX27–206 − 3.1990 0.1089 0.0193
PSAP PSAP-201 4.0106 16.1183 0.0283 CARD10 CARD10–203 −2.9708 0.1276 0.0235
EIF4G1 EIF4G1–221 3.7234 13.2089 0.0349 JADE3 JADE3–203 − 2.7405 0.1496 0.0000
ANGPTL4 ANGPTL4–202 3.5879 12.0241 0.0008 APOL2 APOL2–201 −2.7045 0.1534 0.0246
NDUFS8 NDUFS8–210 3.3598 10.2658 0.0235 POLR2A POLR2A-201 −2.5492 0.1709 0.0266
POLR2B POLR2B-213 3.3478 10.1812 0.0213 KIF14 KIF14–202 −2.5153 0.1749 0.0272
SERPINE2 SERPINE2–203 3.3009 9.8552 0.0139 CD59 CD59–203 −2.4796 0.1793 0.0002
HAX1 HAX1–202 3.1570 8.9197 0.0238 KATNA1 KATNA1–205 −2.3728 0.1931 0.0247
CCDC47 CCDC47–207 3.1261 8.7309 0.0229 EIF4G1 EIF4G1–216 −2.3661 0.1940 0.0057
TIPARP TIPARP-206 3.0047 8.0262 0.0214 POLR2B POLR2B-205 −2.3462 0.1967 0.0220
ANGPTL4 ANGPTL4–201 2.9858 7.9219 0.0001 ATP5G2 ATP5G2–204 −2.3328 0.1985 0.0145
UBA2 UBA2–208 2.8114 7.0199 0.0272 NOP2 NOP2–203 −2.3103 0.2016 0.0275
EIF4G1 EIF4G1–207 2.6434 6.2481 0.0280 GPANK1 GPANK1–201 −2.2093 0.2162 0.0022
PPP2R2A PPP2R2A-201 2.5557 5.8797 0.0221 SEC22C SEC22C-205 −2.1893 0.2193 0.0258
PDK4 PDK4–201 2.5308 5.7790 0.0000 ALPI ALPI-201 −2.1868 0.2196 0.0045
ZFAND2B ZFAND2B-206 2.4906 5.6202 0.0000 CTSA CTSA-201 −2.1791 0.2208 0.0134
DDX19B DDX19B-208 2.4219 5.3586 0.0370 ALDH3B1 ALDH3B1–208 −2.1746 0.2215 0.0139
ZYX ZYX-203 2.4101 5.3151 0.0480 MEOX1 MEOX1–202 −2.1356 0.2276 0.0000
WASHC5 WASHC5–202 2.2769 4.8462 0.0226 SNX3 SNX3–204 −2.1237 0.2295 0.0156