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Table 2 Effects of insulin and intralipid infusion in control and PCOS subjects before exercise

From: Regulation of circulating CTRP-2/CTRP-9 and GDF-8/GDF-15 by intralipids and insulin in healthy control and polycystic ovary syndrome women following chronic exercise training

Study Design ➔ Saline Study
• Saline: 0 to 5 H
• Insulin and glucose: 3 to 5 H
Intralipid Study
• Intralipid: 0 to 5 H
• Insulin and glucose: 3 to 5 H
CTRPs & GDFs Time (H) Control
(N = 9)
PCOS
(N = 10)
Control
(N = 9)
PCOS
(N = 10)
CTRP2 (ng/mL) 0 1.6 ± 0.4 1.5 ± 0.5 1.9 ± 0.6 1.7 ± 0.7
3H 1.6 ± 0.6 1.8 ± 0.7 4.9 ± 2.4a,d 3.9 ± 2.2a,d
5H 1.9 ± 1.0 2.1 ± 1.0 4.7 ± 1.7a,d 4.4 ± 1.9a,d
CTRP9 (ng/mL) 0 62.8 ± 19.2 56.6 ± 19.1 62.9 ± 23.1 56.9 ± 23.1
3H 65.3 ± 18.9 58.4 ± 15.4 69.4 ± 23.2 65.4 ± 27.2
5H 70.3 ± 24.9 57.3 ± 15.7 57.8 ± 22.8b 53.8 ± 30.9b
GDF8 (ng/mL) 0 2.3 ± 1.1 3.1 ± 1.8 2.8 ± 1.1 2.8 ± 1.2
3H 2.0 ± 0.8 2.7 ± 1.2 2.8 ± 1.0 2.6 ± 1.1
5H 1.7 ± 0.7a 2.3 ± 0.9a 2.4 ± 0.7d 2.6 ± 1.0
GDF15 (ng/mL) 0 0.5 ± 0.2 0.6 ± 0.2 0.7 ± 0.4 0.7 ± 0.3
3H 0.8 ± 0.5 0.7 ± 0.2 0.7 ± 0.4 0.7 ± 0.2
5H 0.9 ± 0.6a 0.8 ± 0.2 1.2 ± 1.0 1.2 ± 0.8b
  1. The data are represented as Mean ± SD
  2. Statistical significance (P < 0.05) is shown in the table with superscripts a, b, c and d
  3. a compares 3H or 5H versus 0; b compares 5H versus 3H; c compares PCOS values versus respective control values; and d compares intralipid values versus respective saline values
  4. CTRPs C1Q/TNF related proteins, GDFs Growth differentiation factors
  5. a, b and d: Student’s paired t-test; c: Two-way ANOVA