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Table 2 Effects of insulin and intralipid infusion in control and PCOS subjects before exercise

From: Regulation of circulating CTRP-2/CTRP-9 and GDF-8/GDF-15 by intralipids and insulin in healthy control and polycystic ovary syndrome women following chronic exercise training

Study Design âž”

Saline Study

• Saline: 0 to 5 H

• Insulin and glucose: 3 to 5 H

Intralipid Study

• Intralipid: 0 to 5 H

• Insulin and glucose: 3 to 5 H

CTRPs & GDFs

Time (H)

Control

(N = 9)

PCOS

(N = 10)

Control

(N = 9)

PCOS

(N = 10)

CTRP2 (ng/mL)

0

1.6 ± 0.4

1.5 ± 0.5

1.9 ± 0.6

1.7 ± 0.7

3H

1.6 ± 0.6

1.8 ± 0.7

4.9 ± 2.4a,d

3.9 ± 2.2a,d

5H

1.9 ± 1.0

2.1 ± 1.0

4.7 ± 1.7a,d

4.4 ± 1.9a,d

CTRP9 (ng/mL)

0

62.8 ± 19.2

56.6 ± 19.1

62.9 ± 23.1

56.9 ± 23.1

3H

65.3 ± 18.9

58.4 ± 15.4

69.4 ± 23.2

65.4 ± 27.2

5H

70.3 ± 24.9

57.3 ± 15.7

57.8 ± 22.8b

53.8 ± 30.9b

GDF8 (ng/mL)

0

2.3 ± 1.1

3.1 ± 1.8

2.8 ± 1.1

2.8 ± 1.2

3H

2.0 ± 0.8

2.7 ± 1.2

2.8 ± 1.0

2.6 ± 1.1

5H

1.7 ± 0.7a

2.3 ± 0.9a

2.4 ± 0.7d

2.6 ± 1.0

GDF15 (ng/mL)

0

0.5 ± 0.2

0.6 ± 0.2

0.7 ± 0.4

0.7 ± 0.3

3H

0.8 ± 0.5

0.7 ± 0.2

0.7 ± 0.4

0.7 ± 0.2

5H

0.9 ± 0.6a

0.8 ± 0.2

1.2 ± 1.0

1.2 ± 0.8b

  1. The data are represented as Mean ± SD
  2. Statistical significance (P < 0.05) is shown in the table with superscripts a, b, c and d
  3. a compares 3H or 5H versus 0; b compares 5H versus 3H; c compares PCOS values versus respective control values; and d compares intralipid values versus respective saline values
  4. CTRPs C1Q/TNF related proteins, GDFs Growth differentiation factors
  5. a, b and d: Student’s paired t-test; c: Two-way ANOVA