Skip to main content

Table 4 Effects of insulin and intralipid infusion in control and PCOS subjects after exercise

From: Regulation of circulating CTRP-2/CTRP-9 and GDF-8/GDF-15 by intralipids and insulin in healthy control and polycystic ovary syndrome women following chronic exercise training

Study Design ➔ Saline Study
• Saline: 0 to 5 H
• Insulin and glucose: 3 to 5 H
Intralipid Study
• Intralipid: 0 to 5 H
• Insulin and glucose: 3 to 5 H
Clinical Variables Time (H) Control
(N = 9)
PCOS
(N = 10)
Control
(N = 9)
PCOS
(N = 10)
CTRP2 (ng/mL) 0 1.7 ± 0.6 1.7 ± 0.6 1.7 ± 0.5 1.6 ± 0.6
3H 1.7 ± 0.6 1.8 ± 0.7 3.2 ± 1.4a,d 3.4 ± 1.2a,d
5H 2.1 ± 1.4 2.3 ± 0.8 3.6 ± 1.6a 3.5 ± 1.1a,d
CTRP9 (ng/mL) 0 59.9 ± 37.4 54.3 ± 23.9 66.1 ± 27.7 65.8 ± 17.5
3H 80.4 ± 49.8 70.1 ± 17.6 67.7 ± 34.8 67.5 ± 22.3
5H 74.5 ± 49.2 69.7 ± 24.4 60.1 ± 44.9 59.5 ± 14.9
GDF8 (ng/mL) 0 1.3 ± 0.4 1.6 ± 0.6 1.6 ± 0.9 1.6 ± 0.9
3H 1.2 ± 0.3 1.5 ± 0.4 2.5 ± 0.8a,d 2.6 ± 1.0a,d
5H 1.0 ± 0.3a,b 1.3 ± 0.5 2.1 ± 0.9d 2.2 ± 1.1a,b,d
GDF15 (ng/mL) 0 0.5 ± 0.3 0.6 ± 0.2 0.7 ± 0.2 0.7 ± 0.2
3H 0.3 ± 0.2a 0.6 ± 0.5 0.5 ± 0.4 0.5 ± 0.4
5H 0.5 ± 0.3b 0.9 ± 0.4b,c 0.9 ± 0.9 1.1 ± 0.9b
  1. The data are represented as Mean ± SD
  2. Statistical significance (P < 0.05) is shown in the table with superscripts a, b, c and d
  3. a compares 3H or 5H versus 0; b compares 5H versus 3H; c compares PCOS values versus respective control values at different time point; and d compares intralipid values versus respective saline values
  4. CTRPs C1Q/TNF related proteins, GDFs Growth differentiation factors
  5. a, b and d: Student’s paired t-test, c: Two-way ANOVA