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Table 4 Effects of insulin and intralipid infusion in control and PCOS subjects after exercise

From: Regulation of circulating CTRP-2/CTRP-9 and GDF-8/GDF-15 by intralipids and insulin in healthy control and polycystic ovary syndrome women following chronic exercise training

Study Design âž”

Saline Study

• Saline: 0 to 5 H

• Insulin and glucose: 3 to 5 H

Intralipid Study

• Intralipid: 0 to 5 H

• Insulin and glucose: 3 to 5 H

Clinical Variables

Time (H)

Control

(N = 9)

PCOS

(N = 10)

Control

(N = 9)

PCOS

(N = 10)

CTRP2 (ng/mL)

0

1.7 ± 0.6

1.7 ± 0.6

1.7 ± 0.5

1.6 ± 0.6

3H

1.7 ± 0.6

1.8 ± 0.7

3.2 ± 1.4a,d

3.4 ± 1.2a,d

5H

2.1 ± 1.4

2.3 ± 0.8

3.6 ± 1.6a

3.5 ± 1.1a,d

CTRP9 (ng/mL)

0

59.9 ± 37.4

54.3 ± 23.9

66.1 ± 27.7

65.8 ± 17.5

3H

80.4 ± 49.8

70.1 ± 17.6

67.7 ± 34.8

67.5 ± 22.3

5H

74.5 ± 49.2

69.7 ± 24.4

60.1 ± 44.9

59.5 ± 14.9

GDF8 (ng/mL)

0

1.3 ± 0.4

1.6 ± 0.6

1.6 ± 0.9

1.6 ± 0.9

3H

1.2 ± 0.3

1.5 ± 0.4

2.5 ± 0.8a,d

2.6 ± 1.0a,d

5H

1.0 ± 0.3a,b

1.3 ± 0.5

2.1 ± 0.9d

2.2 ± 1.1a,b,d

GDF15 (ng/mL)

0

0.5 ± 0.3

0.6 ± 0.2

0.7 ± 0.2

0.7 ± 0.2

3H

0.3 ± 0.2a

0.6 ± 0.5

0.5 ± 0.4

0.5 ± 0.4

5H

0.5 ± 0.3b

0.9 ± 0.4b,c

0.9 ± 0.9

1.1 ± 0.9b

  1. The data are represented as Mean ± SD
  2. Statistical significance (P < 0.05) is shown in the table with superscripts a, b, c and d
  3. a compares 3H or 5H versus 0; b compares 5H versus 3H; c compares PCOS values versus respective control values at different time point; and d compares intralipid values versus respective saline values
  4. CTRPs C1Q/TNF related proteins, GDFs Growth differentiation factors
  5. a, b and d: Student’s paired t-test, c: Two-way ANOVA