Fig. 4From: Sphingolipid lysosomal storage diseases: from bench to bedsideSummary of the major cellular interactions leading to the neurological features of sphingolipidoses. A schematic of the main events that lead to caspase-dependent and independent activation of neuronal apoptosis through myriad intercalated pathways, such as the disruption of TFEEB fine-tuning, impaired Ca2+ homeostasis in smooth ER, mitochondria and lysosomes, lysosomal membrane permeabilization, and impaired autophagy, along with others (not depicted here). Proteins are depicted in oblong shapes, while lipids are in circles and cellular events are in rectangles. Upward green arrows represent increase in cellular concentration while downward red arrows illustrate decreased concentration. Note that organellar sizes are not to scale. not to scale. This figure was created in Biorender.comBack to article page