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Table 3 Univariate analysis of factors associated with severity, mortality, ARDS, and ARF in AP

From: Accuracy of conventional and novel scoring systems in predicting severity and outcomes of acute pancreatitis: a retrospective study

Characteristic Severity Mortality ARDS ARF
  Mild
(n = 1164)
Severe
(n = 684)
P Survivor
(n = 1782)
Non-survivor
(n = 66)
P No
(n = 1735)
Yes
(n = 113)
P No
(n = 1706)
Yes
(n = 142)
P
Age, y 46.22 (15.40) 51.62 (16.99) < 0.001 48.07 (16.10) 52.09 (18.69) 0.048 48.12 (16.18) 49.79 (16.66) 0.288 48.12 (16.22) 49.41 (16.12) 0.363
Male gender, n (%) 783 (67.27) 477 (69.74) 0.271 1210 (67.90) 50 (75.76) 0.178 1175 (67.72) 85 (75.22) 0.097 1142 (66.94) 118 (83.10) < 0.001
BMI, kg/m2 23.43 (4.26) 24.73 (4.52) < 0.001 23.99 (4.45) 23.07 (2.92) 0.293 23.85 (4.39) 25.44 (4.44) 0.009 23.85 (4.33) 25.51 (5.16) 0.006
Comorbidities, n (%)
 Hyperlipidemia 169 (14.52) 106 (15.50) 0.568 267 (14.98) 8 (12.12) 0.521 257 (14.81) 18 (15.93) 0.747 245 (14.36) 30 (21.13) 0.03
 T2DM 85 (7.30) 54 (7.89) 0.641 134 (7.52) 5 (7.58) 0.986 130 (7.49) 9 (7.96) 0.854 135 (7.91) 4 (2.82) 0.013
Etiology, n (%)
 Gallstones 467 (40.12) 244 (35.67) 0.058 697 (39.11) 14 (21.21) 0.003 681 (39.25) 30 (26.55) 0.007 679 (39.80) 32 (22.54) < 0.001
 Alcoholism 101 (8.68) 98 (14.33) < 0.001 191 (10.72) 8 (12.12) 0.718 178 (10.26) 21 (18.58) 0.006 169 (9.91) 30 (21.13) < 0.001
 Hypertriglyceridemia 186 (15.98) 123 (17.98) 0.265 301 (16.89) 11 (16.67) 0.308 288 (16.60) 21 (18.58) 0.584 278 (16.30) 31 (21.83) 0.089
Smoker, n (%) 337 (28.95) 204 (29.82) 0.691 525 (29.46) 16 (24.24) 0.36 505 (29.11) 36 (31.86) 0.533 490 (28.72) 51 (35.92) 0.07
Alcohol intake history, n (%) 334 (28.69) 257 (37.57) < 0.001 568 (31.87) 23 (34.85) 0.611 540 (31.12) 51 (45.13) 0.002 520 (30.48) 71 (50.00) < 0.001
Hospital stay, d 12.35 (8.18) 16.56 (11.95) < 0.001 14.01 (9.68) 10.08 (14.82) 0.042 13.53 (8.85) 19.38 (19.8) 0.003 13.58 (9.02) 17.52 (17.16) 0.009
Death, n (%) 6 (0.52) 60 (8.77) < 0.001 29 (1.67) 37 (32.74) < 0.001 26 (1.52) 40 (28.17) < 0.001
WBC (*109/L) 10.46 (4.96) 14.71 (6.37) < 0.001 11.94 (5.77) 14.58 (8.26) 0.012 11.84 (5.81) 14.89 (6.36) < 0.001 11.79 (5.58) 14.92 (8.28) < 0.001
Hemoglobin (g/L) 127.61 (21.99) 128.11 (30.90) 0.713 128.26 (24.63) 115.28 (43.57) 0.019 127.78 (24.37) 127.99 (40.63) 0.957 127.78 (23.77) 127.99 (42.19) 0.955
Hematocrit 0.46 (1.52) 0.41 (0.52) 0.408 0.45 (1.26) 0.33 (0.10) 0.452 0.45 (1.28) 0.39 (0.15) 0.632 0.45 (1.29) 0.40 (0.23) 0.652
BUN (mmol/L) 4.70 (4.51) 7.06 (6.74) < 0.001 5.35 (5.16) 12.37 (10.53) < 0.001 5.27 (5.01) 10.40 (9.88) < 0.001 4.93 (4.32) 13.50 (10.68) < 0.001
Creatinine (μmol/L) 77.41 (35.51) 109.02 (99.68) < 0.001 85.73 (60.61) 191.88 (159.04) < 0.001 84.88 (58.86) 156.95 (140.72) < 0.001 76.51 (28.59) 244.83 (163.11) < 0.001
Total bilirubin (μmol/L) 38.25 (67.41) 41.66 (52.51) 0.277 38.41 (59.80) 72.16 (107.79) 0.023 39.54 (62.76) 39.40 (53.76) 0.983 39.07 (60.74) 45.55 (79.37) 0.274
Albumin (g/L) 37.78 (7.16) 34.19 (7.33) < 0.001 36.69 (7.31) 28.97 (7.02) < 0.001 36.6.69 (7.36) 32.31 (7.32) < 0.001 36.76 (7.24) 32.04 (8.40) < 0.001
AST (IU/L) 68.94 (113.56) 104.17 (293.67) 0.004 76.66 (121.03) 244.29 (894.16) 0.145 82.42 (206.45) 76.95 (82.21) 0.794 76.34 (120.21) 158.44 (618.75) 0.151
Calcium (mmol/L) 2.20 (0.24) 2.00 (0.33) < 0.001 2.14 (0.27) 1.85 (0.63) 0.001 2.14 (0.27) 1.89 (0.48) < 0.001 2.14 (0.27) 1.90 (0.44) < 0.001
Blood glucose (mmol/L) 7.41 (3.84) 10.21 (5.37) < 0.001 8.25 (4.47) 13.33 (7.78) 0.003 8.20 (4.40) 11.54 (7.09) 0.001 8.12 (4.26) 12.59 (7.69) < 0.001
LDH (IU/L) 234.9 (104.21) 420.76 (235.22) < 0.001 305.78 (186.17) 476.00 (326.16) 0.003 298.31 (177.79) 493.86 (291.49) < 0.001 298.65 (176.75) 475.35 (300.05) < 0.001
Triglycerides (mmol/L) 2.89 (4.37) 4.5 (6.08) < 0.001 3.51 (5.12) 3.99 (6.52) 0.558 3.38 (5.00) 5.60 (6.88) < 0.006 3.27 (4.79) 6.7 (8.06) < 0.001
CRP (mg/L) 78.53 (58.34) 138.28 (60.29) < 0.001 109.77 (66.56) 128.77 (62.19) 0.036 106.83 (65.32) 143.21 (66.71) < 0.001 107.57 (66.88) 134.55 (58.07) < 0.001
Ranson score 0.67 (0.77) 2.57 (1.37) < 0.001 1.34 (1.36) 2.41 (1.58) < 0.001 1.29 (1.33) 2.64 (1.46) < 0.001 1.29 (1.32) 2.45 (1.61) < 0.001
Glasgow score 0.48 (0.69) 2.24 (1.25) < 0.001 1.09 (1.23) 2.39 (1.53) < 0.001 1.05 (1.22) 2.45 (1.20) < 0.001 1.04 (1.20) 2.28 (1.21) < 0.001
BISAP 0.6 (0.72) 1.95 (1.1) < 0.001 1.05 (1.06) 2.42 (1.25) < 0.001 1.01 (1.04) 2.49 (1.00) < 0.001 1.00 (1.02) 2.27 (1.20) < 0.001
PASS 105.51 (52.27) 172.05 (81.08) < 0.001 125.56 (66.82) 253.64 (94.44) < 0.001 120.82 61.05) 273.19 (76.21) < 0.001 120.73 (61.42) 243.11 (91.49) < 0.001
CSSS 0.55 (0.78) 2.12 (1.50) < 0.001 1.08 (1.29) 2.62 (1.69) < 0.001 1.01 (1.22) 2.98 (1.65) < 0.001 0.99 (1.19) 2.89 (1.66) < 0.001
  1. ARDS Acute respiratory distress syndrome, ARF Acute renal failure, AP Acute pancreatitis, BMI Body-mass index, T2DM type-2 diabetes mellitus; WBC White blood cell count, BUN Blood urea nitrogen, CRP C-reactive protein; AST: aspartate transaminase, LDH Lactate dehydrogenase, BISAP Bedside index of severity in acute pancreatitis, PASS Pancreatic activity scoring system, CSSS Chinese simple scoring system. P < 0.05 was accepted as statistically significant