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Table 3 Univariate analysis of factors associated with severity, mortality, ARDS, and ARF in AP

From: Accuracy of conventional and novel scoring systems in predicting severity and outcomes of acute pancreatitis: a retrospective study

Characteristic

Severity

Mortality

ARDS

ARF

 

Mild

(n = 1164)

Severe

(n = 684)

P

Survivor

(n = 1782)

Non-survivor

(n = 66)

P

No

(n = 1735)

Yes

(n = 113)

P

No

(n = 1706)

Yes

(n = 142)

P

Age, y

46.22 (15.40)

51.62 (16.99)

< 0.001

48.07 (16.10)

52.09 (18.69)

0.048

48.12 (16.18)

49.79 (16.66)

0.288

48.12 (16.22)

49.41 (16.12)

0.363

Male gender, n (%)

783 (67.27)

477 (69.74)

0.271

1210 (67.90)

50 (75.76)

0.178

1175 (67.72)

85 (75.22)

0.097

1142 (66.94)

118 (83.10)

< 0.001

BMI, kg/m2

23.43 (4.26)

24.73 (4.52)

< 0.001

23.99 (4.45)

23.07 (2.92)

0.293

23.85 (4.39)

25.44 (4.44)

0.009

23.85 (4.33)

25.51 (5.16)

0.006

Comorbidities, n (%)

 Hyperlipidemia

169 (14.52)

106 (15.50)

0.568

267 (14.98)

8 (12.12)

0.521

257 (14.81)

18 (15.93)

0.747

245 (14.36)

30 (21.13)

0.03

 T2DM

85 (7.30)

54 (7.89)

0.641

134 (7.52)

5 (7.58)

0.986

130 (7.49)

9 (7.96)

0.854

135 (7.91)

4 (2.82)

0.013

Etiology, n (%)

 Gallstones

467 (40.12)

244 (35.67)

0.058

697 (39.11)

14 (21.21)

0.003

681 (39.25)

30 (26.55)

0.007

679 (39.80)

32 (22.54)

< 0.001

 Alcoholism

101 (8.68)

98 (14.33)

< 0.001

191 (10.72)

8 (12.12)

0.718

178 (10.26)

21 (18.58)

0.006

169 (9.91)

30 (21.13)

< 0.001

 Hypertriglyceridemia

186 (15.98)

123 (17.98)

0.265

301 (16.89)

11 (16.67)

0.308

288 (16.60)

21 (18.58)

0.584

278 (16.30)

31 (21.83)

0.089

Smoker, n (%)

337 (28.95)

204 (29.82)

0.691

525 (29.46)

16 (24.24)

0.36

505 (29.11)

36 (31.86)

0.533

490 (28.72)

51 (35.92)

0.07

Alcohol intake history, n (%)

334 (28.69)

257 (37.57)

< 0.001

568 (31.87)

23 (34.85)

0.611

540 (31.12)

51 (45.13)

0.002

520 (30.48)

71 (50.00)

< 0.001

Hospital stay, d

12.35 (8.18)

16.56 (11.95)

< 0.001

14.01 (9.68)

10.08 (14.82)

0.042

13.53 (8.85)

19.38 (19.8)

0.003

13.58 (9.02)

17.52 (17.16)

0.009

Death, n (%)

6 (0.52)

60 (8.77)

< 0.001

29 (1.67)

37 (32.74)

< 0.001

26 (1.52)

40 (28.17)

< 0.001

WBC (*109/L)

10.46 (4.96)

14.71 (6.37)

< 0.001

11.94 (5.77)

14.58 (8.26)

0.012

11.84 (5.81)

14.89 (6.36)

< 0.001

11.79 (5.58)

14.92 (8.28)

< 0.001

Hemoglobin (g/L)

127.61 (21.99)

128.11 (30.90)

0.713

128.26 (24.63)

115.28 (43.57)

0.019

127.78 (24.37)

127.99 (40.63)

0.957

127.78 (23.77)

127.99 (42.19)

0.955

Hematocrit

0.46 (1.52)

0.41 (0.52)

0.408

0.45 (1.26)

0.33 (0.10)

0.452

0.45 (1.28)

0.39 (0.15)

0.632

0.45 (1.29)

0.40 (0.23)

0.652

BUN (mmol/L)

4.70 (4.51)

7.06 (6.74)

< 0.001

5.35 (5.16)

12.37 (10.53)

< 0.001

5.27 (5.01)

10.40 (9.88)

< 0.001

4.93 (4.32)

13.50 (10.68)

< 0.001

Creatinine (μmol/L)

77.41 (35.51)

109.02 (99.68)

< 0.001

85.73 (60.61)

191.88 (159.04)

< 0.001

84.88 (58.86)

156.95 (140.72)

< 0.001

76.51 (28.59)

244.83 (163.11)

< 0.001

Total bilirubin (μmol/L)

38.25 (67.41)

41.66 (52.51)

0.277

38.41 (59.80)

72.16 (107.79)

0.023

39.54 (62.76)

39.40 (53.76)

0.983

39.07 (60.74)

45.55 (79.37)

0.274

Albumin (g/L)

37.78 (7.16)

34.19 (7.33)

< 0.001

36.69 (7.31)

28.97 (7.02)

< 0.001

36.6.69 (7.36)

32.31 (7.32)

< 0.001

36.76 (7.24)

32.04 (8.40)

< 0.001

AST (IU/L)

68.94 (113.56)

104.17 (293.67)

0.004

76.66 (121.03)

244.29 (894.16)

0.145

82.42 (206.45)

76.95 (82.21)

0.794

76.34 (120.21)

158.44 (618.75)

0.151

Calcium (mmol/L)

2.20 (0.24)

2.00 (0.33)

< 0.001

2.14 (0.27)

1.85 (0.63)

0.001

2.14 (0.27)

1.89 (0.48)

< 0.001

2.14 (0.27)

1.90 (0.44)

< 0.001

Blood glucose (mmol/L)

7.41 (3.84)

10.21 (5.37)

< 0.001

8.25 (4.47)

13.33 (7.78)

0.003

8.20 (4.40)

11.54 (7.09)

0.001

8.12 (4.26)

12.59 (7.69)

< 0.001

LDH (IU/L)

234.9 (104.21)

420.76 (235.22)

< 0.001

305.78 (186.17)

476.00 (326.16)

0.003

298.31 (177.79)

493.86 (291.49)

< 0.001

298.65 (176.75)

475.35 (300.05)

< 0.001

Triglycerides (mmol/L)

2.89 (4.37)

4.5 (6.08)

< 0.001

3.51 (5.12)

3.99 (6.52)

0.558

3.38 (5.00)

5.60 (6.88)

< 0.006

3.27 (4.79)

6.7 (8.06)

< 0.001

CRP (mg/L)

78.53 (58.34)

138.28 (60.29)

< 0.001

109.77 (66.56)

128.77 (62.19)

0.036

106.83 (65.32)

143.21 (66.71)

< 0.001

107.57 (66.88)

134.55 (58.07)

< 0.001

Ranson score

0.67 (0.77)

2.57 (1.37)

< 0.001

1.34 (1.36)

2.41 (1.58)

< 0.001

1.29 (1.33)

2.64 (1.46)

< 0.001

1.29 (1.32)

2.45 (1.61)

< 0.001

Glasgow score

0.48 (0.69)

2.24 (1.25)

< 0.001

1.09 (1.23)

2.39 (1.53)

< 0.001

1.05 (1.22)

2.45 (1.20)

< 0.001

1.04 (1.20)

2.28 (1.21)

< 0.001

BISAP

0.6 (0.72)

1.95 (1.1)

< 0.001

1.05 (1.06)

2.42 (1.25)

< 0.001

1.01 (1.04)

2.49 (1.00)

< 0.001

1.00 (1.02)

2.27 (1.20)

< 0.001

PASS

105.51 (52.27)

172.05 (81.08)

< 0.001

125.56 (66.82)

253.64 (94.44)

< 0.001

120.82 61.05)

273.19 (76.21)

< 0.001

120.73 (61.42)

243.11 (91.49)

< 0.001

CSSS

0.55 (0.78)

2.12 (1.50)

< 0.001

1.08 (1.29)

2.62 (1.69)

< 0.001

1.01 (1.22)

2.98 (1.65)

< 0.001

0.99 (1.19)

2.89 (1.66)

< 0.001

  1. ARDS Acute respiratory distress syndrome, ARF Acute renal failure, AP Acute pancreatitis, BMI Body-mass index, T2DM type-2 diabetes mellitus; WBC White blood cell count, BUN Blood urea nitrogen, CRP C-reactive protein; AST: aspartate transaminase, LDH Lactate dehydrogenase, BISAP Bedside index of severity in acute pancreatitis, PASS Pancreatic activity scoring system, CSSS Chinese simple scoring system. P < 0.05 was accepted as statistically significant