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Table 1 Biochemical and clinical characteristics of patients with FCHL in the overall population and stratified by FCHL dyslipidemia phenotype

From: Comparative assessment of LDL-C and VLDL-C estimation in familial combined hyperlipidemia using Sampson’s, Martin’s and Friedewald’s equations

Variable

Overall

n = 340

Isolated hypercholesterolemia

n = 137

Mixed dyslipidemia

n = 203

P

Sex (female)

221 (65.0)

105 (76.6)

116 (57.1)

< 0.001

Age (years)

47.0 (35.0–58.0)

43.0 (32.0–57.0)

48.0 (37.0–58.0)

0.019

Type 2 Diabetes (%)

65 (19.1)

10 (7.3)

55 (27.1)

< 0.001

Hypertension (%)

70 (20.6)

21 (15.3)

49 (24.3)

0.046

Total cholesterol (mg/dL)

209.0 (179.0–241.5)

179.0 (160.0–198.8)

226.5 (206.0–266.8)

< 0.001

HDL cholesterol (mg/dL)

42.0 (35.0–48.8)

47.0 (41.0–54.0)

38.0 (33.0–44.0)

< 0.001

Non-HDL cholesterol (mg/dL)

168.0 (133.0–198.0)

129.5 (112.0–154.8)

188.0 (168.3–227.0)

< 0.001

Triglycerides (mg/dL)

182.5 (107.3–310.3)

99.0 (73.0–122.3)

271.0 (205.5–394.8)

< 0.001

Apolipoprotein B (mg/dL)

116.0 (90.0–136.8)

87.0 (72.9–103.8)

128.5 (114.3–148.8)

< 0.001

VLDL-Triglycerides (mg/dL)

120.8 (61.3–240.1)

54.7 (34.0–73.9)

211.0 (144.2–329.9)

< 0.001

VLDL-Cholesterol (mg/dL)

32.4 (16.5–52.5)

14.7 (9.1–19.7)

49.0 (36.1–67.4)

< 0.001

VLDL-Cholesterol Martin (mg/dL)

32.9 (21.3–46.0)

19.7 (16.0–22.9)

43.5 (34.5–56.4)

< 0.001

VLDL-Cholesterol Sampson (mg/dL)

35.1 (18.6–54.4)

16.5 (12.0–20.9)

51.6 (37.8–69.7)

< 0.001

VLDL-Cholesterol Friedewald (mg/dL)

36.5 (21.5–62.1)

19.8 (14.6–24.5)

54.2 (41.1–79.0)

< 0.001

LDL-Cholesterol (mg/dL) *

127.7 (106.4–151.6)

114.2 (98.4–136.9)

139.0 (119.4–161.7)

< 0.001

LDL-cholesterol Martin (mg/dL)

130.1 (106.2–151.4)

109.4 (95.0–131.4)

142.9 (121.5–162.3)

< 0.001

LDL-Cholesterol Sampson (mg/dL)

127.8 (101.1–145.8)

111.8 (95.6–133.1)

134.6 (110.7–157.5)

< 0.001

LDL-Cholesterol Friedewald (mg/dL)

122.6 (97.2–142.4)

109.4 (94.4–130.9)

128.8 (102.1–153.5)

< 0.001

Statin treatment (%)

41 (12.0)

5 (3.6)

36 (17.7)

< 0.001