Comparative assessment of LDL-C and VLDL-C estimation in familial combined hyperlipidemia using Sampson’s, Martin’s and Friedewald’s equations

Vargas-Vázquez, Arsenio; Bello-Chavolla, Omar Yaxmehen; Antonio-Villa, Neftali Eduardo; Mehta, Roopa; Cruz-Bautista, Ivette; Aguilar-Salinas, Carlos A.

doi:10.1186/s12944-021-01471-3

Lipids in Health and Disease

Table 3 Comparison of lipid targets for all three formulas compared to LDL-C estimated using VLDL-C measured by ultracentrifugation in the overall population and stratified by FCHL dyslipidemia phenotype

From: Comparative assessment of LDL-C and VLDL-C estimation in familial combined hyperlipidemia using Sampson’s, Martin’s and Friedewald’s equations

Metric		LDL-F	LDL-M	LDL-S	Isolated Hypercholesterolemia			Mixed dyslipidemia
Metric		LDL-F	LDL-M	LDL-S	LDL-F	LDL-M	LDL-S	LDL-F	LDL-M	LDL-S
LDL-C goal < 100 mg/dL	κ (95%CI)	0.730 (0.642–0.818)	0.764 (0.674–0.854)	0.819 (0.740–0.997)	0.723 (0.630–0.843)	0.752 (0.636–0.868)	0.779 (0.666–0.892)	0.709 (0.568–0.850)	0.731 (0.566–0.897)	0.852 (0.735–0.968)
LDL-C goal < 100 mg/dL	AUC (95%CI)	0.923 (0.884–0.961)	0.892 (0.835–0.948)	0.933 (0.890–975)	0.898 (0.839–0.956)	0.909 (0.851–0.965)	0.911 (0.851–0.970)	0.938 (0.883–0.994)	0.815 (0.690–0.940)	0.943 (0.871–1.00)
LDL-C goal < 70 mg/dL	κ (95%CI)	0.338 (0.127–0.549)	0.506 (0.252–0.759)	0.462 (0.216–0.707)	0.560 (0.115–1.00)	0.453 (0.012–0.839)	0.560 (0.115–1.00)	0.279 (0.054–0.504)	0.557 (0.242–0.872)	0.424 (0.136–0.712)
LDL-C goal < 70 mg/dL	AUC (95%CI)	0.870 (0.750–0.990)	0.869 (0.742–0.995)	0.878 (0.759–0.997)	0.730 (0.412–1.00)	0.727 (0.405–1.00)	0.731 (0.409–1.00)	0.942 (0.877–1.00)	0.929 (0.816–1.00)	0.951 (0.877–1.00)
ApoB goal < 65 mg/dL	κ (95%CI)	0.081 (−0.066–0.228)	0.269 (0.059–0.478)	0.127 (− 0.047–0.301)	0.159 (− 0.054–0.371)	0.308 (0.063.0.553)	0.159 (− 0.054–0.371)	0.07 (− 0.082–0.230)	0.187 (−0.143–0.517)	0.128 (− 0.115,0.371)
ApoB goal < 65 mg/dL	AUROC (95%CI)	0.869 (0.815–0.922)	0.915 (0.858–0.971)	0.898 (0.841–0.954)	0.931 (0.882–0.980)	0.935 (0.887–0.982)	0.935 (0.888–0.982)	0763 (0.394–1.00)	0.775 (0.373–1.00)	0.763 (0.325–1.00)
ApoB goal < 80 mg/dL	κ (95%CI)	0.450 (0.342–0.558)	0.570 (0.459–0.681)	0.463 (0.347–0.579)	0.674 (0.547–0.802)	0.672 (0.554–0.800)	0.605 (0.467–0.742)	0.024 (−0.044,0.091)	0.060 (−0.071,0.190)	0.039 (− 0.056,0.137)
ApoB goal < 80 mg/dL	AUROC (95%CI)	0.827 (0.785–0.872)	0.905 (0.870–0.939)	0.867 (0.827–0.906)	0.910 (0.863–0.957)	0.918 (0.873–0.963)	0.913 (0.867–0.959)	0.762 (0.394–1.00)	0.775 (0.373–1.00)	0.763 (0.325–1.00)

Abbreviations: AUROC Area Under the ROC Curve, 95%CI 95% Confidence Interval, LDL-F LDL-C estimated by the Friedewald’s equation, LDL-M LDL-C estimated by Martin’s formula, LDL-S LDL-C estimated by Sampson’s formula

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