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Table 3 Univariate and Multivariate Cox regression model of patients’ characteristics and MACE events

From: Pcsk9 is associated with severity of coronary artery lesions in male patients with premature myocardial infarction

Variables Univariate Multivariate
HR (95% CI) P-value aHR (95% CI) P-value
Age, years 1.07 (0.98, 1.18) 0.150
Body mass index, kg/m2 1.14 (0.91, 1.42) 0.250
SBP, mmHg 1.02 (1.01, 1.03) 0.030* 1.01 (0.99, 1.03) 0.168
Past history
 Hypertension 1.15 (0.55, 2.41) 0.710
 Diabetes 1.59 (0.64, 3.93) 0.320
 Familial history of PCAD 1.79 (0.68, 4.71) 0.240
 Smoking 2.55 (0.77, 8.44) 0.130
Biochemistry
 White blood cells, 109/L 0.99 (0.87, 1.12) 0.890
 Urea, mmol/L 1.22 (1.01, 1.48) 0.047* 1.02 (0.77, 1.35) 0.896
 Lp(a), nmol/L 0.99 (0.99–1.00) 0.407
 TC, mmol/L 0.97 (0.69, 1.36) 0.850
 LDL-C, mmol/L 0.96 (0.67, 1.37) 0.820
 LDL-C > 2.6 mmol/L 1.57 (0.59, 4.14) 0.360
 VLDL-C, mmol/L 1.00 (0.65, 1.53) 0.990
 Apob, g/L 1.10 (0.32, 3.83) 0.880
 HDL-C, mmol/L 1.52 (0.68, 5.87) 0.130
 Triglycerides, mmol/L 1.06 (0.92, 1.22) 0.450
 ALT, U/L 1.00 (0.99, 1.01) 0.880
 Glucose, mmol/L 1.07 (1.00, 1.13) 0.040* 0.99 (0.93, 1.08) 0.977
 Creatinine, μmol/L 1.02 (1.01, 1.03) < 0.001* 1.01 (0.98, 1.03) 0.592
Ischemic heart disease
 LVEF, % 0.99 (0.94, 1.04) 0.560
 Creatine kinase, U/L 1.00 (1.00, 1.00) 0.950
 c-Tnt, ng/Ml 1.03 (0.92, 1.16) 0.590
 hs-Crp, mg/L 1.00 (0.99, 1.01) 0.910
 NT-proBnp, pg/mL 1.00 (1.00, 1.00) 0.170
SYNTAX score > 21.5 1.01 (0.97, 1.06) 0.540
SYNTAX score 1.13 (0.52, 2.45) 0.750
Biomarker
Pcsk9, ng/mL 1.01 (1.004, 1.011) < 0.001* 1.01 (1.00, 1.01) < 0.001*
   < 122.92 Ref. Ref.   
  122.92–204.13 0.15 (0.57, 4.10) 0.400
  204.13 2.28 (0.90, 5.82) 0.080
  1. Variables are presented as adjusted hazard ratio (aHR), 95% confidence interval (95% CI), P-values were derived from univariate or multivariate analysis. *P < 0.05
  2. SBP systolic blood pressure, PCAD premature coronary artery disease, Lp(a) Lipoprotein a, TC total cholesterol, LDL-C low density lipoprotein cholesterol, Apob apolipoprotein B, HDL-C high density lipoprotein cholesterol, ALT alanine transaminase, LVEF left ventricular ejection fraction, hs-Crp high-sensitivity C-reactive protein, c-Tnt cardiac Troponin T, NT-proBnp N-terminal pro-B type natriuretic peptide, Pcsk9 proprotein convertase subtilisin/kexin type 9