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Table 2 GWAS identified SNPs Associated with Lp(a) Level

From: Association of Lipoprotein (a) variants with risk of cardiovascular disease: a Mendelian randomization study

SNP gene Genomic Coordinate EA/OA MAF HWE(P) β SE P Value
rs1018234 SLC22A3 Chr6: 160375026 T/C 0.3798 0.76208 −0.10526 0.04359 0.0158924620
rs117052562 Chr6: 160689582 A/G 0.0510 0.98824 0.34649 0.09508 0.0002792119
rs1406888 Chr6: 160670561 C/T 0.4591 0.84080 −0.11589 0.04178 0.0056265889
rs14224 PLG Chr6: 160716747 C/T 0.4669 0.75426 −0.03305 0.04251 0.4370000000
rs1510224 LPAL2 Chr6: 160473846 C/T 0.0739 0.52604 0.03701 0.08178 0.6509000000
rs2048327 SLC22A3 Chr6: 160442500 C/T 0.4502 0.99758 0.10507 0.04207 0.0126382227
rs2140650 MAP3K4 Chr6: 161087406 G/A 0.3442 0.89826 0.04999 0.04449 0.2614000000
rs2457574 SLC22A3 Chr6: 160447669 G/A 0.4542 0.99196 0.10907 0.04193 0.0094065915
rs2504921 LPAL2 Chr6: 160472974 T/G 0.3637 0.57725 0.07793 0.04293 0.0697000000
rs3127599 LPAL2 Chr6: 160486102 T/C 0.1507 0.86040 −0.00228 0.05921 0.9694000000
rs3798220 LPA Chr6: 160540105 C/T 0.0748 0.92082 0.0249 0.08039 0.7568000000
rs41269133 Chr6: 160666831 C/T 0.2293 0.98939 −0.54028 0.04781 2.92E-28
rs429358 APOE Chr19: 44908684 C/T 0.0829 0.97570 −0.19333 0.07645 0.0115732887
rs505151 PCSK9 Chr1: 55063514 G/A 0.0717 0.98202 0.10972 0.08146 0.1783000000
rs520829 SLC22A3 Chr6: 160346873 G/T 0.3157 0.72279 −0.11847 0.04555 0.0094079135
rs56393506 Chr6: 160668275 T/C 0.1778 0.81177 0.71204 0.05135 9.08E-41
rs5925 LDLR Chr19: 11120205 C/T 0.2178 0.36628 0.07037 0.05181 0.1746000000
rs5927 LDLR Chr19: 11123265 A/G 0.0518 0.93586 −0.09713 0.09432 0.3033000000
rs5929 LDLR Chr19: 11116124 T/C 0.3062 0.97795 −0.01452 0.04569 0.7506000000
rs5930 LDLR Chr19: 11113589 A/G 0.3665 0.16534 −0.08394 0.04471 0.0607000000
rs6415084 LPA Chr6: 160559298 T/C 0.1663 0.67734 0.62622 0.05342 3.51E-30
rs641990 SLC22A3 Chr6: 160358102 A/G 0.3945 0.58243 −0.07539 0.04388 0.0860000000
rs662145 PCSK9 Chr1: 55064155 C/T 0.1231 0.03321 0.12342 0.06155 0.0451562913
rs688 LDLR Chr19: 11116926 T/C 0.1618 0.72698 0.05544 0.05762 0.3362000000
rs7412 APOE Chr19: 44908822 T/C 0.0809 0.15342 −0.14293 0.07983 0.0736000000
rs7765781 LPA Chr6: 160586464 C/G 0.4021 0.17321 −0.41375 0.04012 5.45E-24
rs7770628 LPA Chr6: 160597142 C/T 0.1835 0.95012 0.70012 0.05102 5.09E-40
rs783147 PLG Chr6: 160716958 G/A 0.4980 0.51151 −0.0018 0.04264 0.9664000000
rs9457778 Chr6: 159932259 C/T 0.3705 0.22391 0.09361 0.04241 0.0274770059
  1. SNP single nucleotide polymorphism, EA/OA effect allele/ other allele, MAF minor allele frequency, HWE(P) P value of Hardy-Weinberg equilibrium, SE standard error; sex and age were included into models for adjustment