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Table 2 GWAS identified SNPs Associated with Lp(a) Level

From: Association of Lipoprotein (a) variants with risk of cardiovascular disease: a Mendelian randomization study

SNP

gene

Genomic Coordinate

EA/OA

MAF

HWE(P)

β

SE

P Value

rs1018234

SLC22A3

Chr6: 160375026

T/C

0.3798

0.76208

−0.10526

0.04359

0.0158924620

rs117052562

–

Chr6: 160689582

A/G

0.0510

0.98824

0.34649

0.09508

0.0002792119

rs1406888

–

Chr6: 160670561

C/T

0.4591

0.84080

−0.11589

0.04178

0.0056265889

rs14224

PLG

Chr6: 160716747

C/T

0.4669

0.75426

−0.03305

0.04251

0.4370000000

rs1510224

LPAL2

Chr6: 160473846

C/T

0.0739

0.52604

0.03701

0.08178

0.6509000000

rs2048327

SLC22A3

Chr6: 160442500

C/T

0.4502

0.99758

0.10507

0.04207

0.0126382227

rs2140650

MAP3K4

Chr6: 161087406

G/A

0.3442

0.89826

0.04999

0.04449

0.2614000000

rs2457574

SLC22A3

Chr6: 160447669

G/A

0.4542

0.99196

0.10907

0.04193

0.0094065915

rs2504921

LPAL2

Chr6: 160472974

T/G

0.3637

0.57725

0.07793

0.04293

0.0697000000

rs3127599

LPAL2

Chr6: 160486102

T/C

0.1507

0.86040

−0.00228

0.05921

0.9694000000

rs3798220

LPA

Chr6: 160540105

C/T

0.0748

0.92082

0.0249

0.08039

0.7568000000

rs41269133

–

Chr6: 160666831

C/T

0.2293

0.98939

−0.54028

0.04781

2.92E-28

rs429358

APOE

Chr19: 44908684

C/T

0.0829

0.97570

−0.19333

0.07645

0.0115732887

rs505151

PCSK9

Chr1: 55063514

G/A

0.0717

0.98202

0.10972

0.08146

0.1783000000

rs520829

SLC22A3

Chr6: 160346873

G/T

0.3157

0.72279

−0.11847

0.04555

0.0094079135

rs56393506

–

Chr6: 160668275

T/C

0.1778

0.81177

0.71204

0.05135

9.08E-41

rs5925

LDLR

Chr19: 11120205

C/T

0.2178

0.36628

0.07037

0.05181

0.1746000000

rs5927

LDLR

Chr19: 11123265

A/G

0.0518

0.93586

−0.09713

0.09432

0.3033000000

rs5929

LDLR

Chr19: 11116124

T/C

0.3062

0.97795

−0.01452

0.04569

0.7506000000

rs5930

LDLR

Chr19: 11113589

A/G

0.3665

0.16534

−0.08394

0.04471

0.0607000000

rs6415084

LPA

Chr6: 160559298

T/C

0.1663

0.67734

0.62622

0.05342

3.51E-30

rs641990

SLC22A3

Chr6: 160358102

A/G

0.3945

0.58243

−0.07539

0.04388

0.0860000000

rs662145

PCSK9

Chr1: 55064155

C/T

0.1231

0.03321

0.12342

0.06155

0.0451562913

rs688

LDLR

Chr19: 11116926

T/C

0.1618

0.72698

0.05544

0.05762

0.3362000000

rs7412

APOE

Chr19: 44908822

T/C

0.0809

0.15342

−0.14293

0.07983

0.0736000000

rs7765781

LPA

Chr6: 160586464

C/G

0.4021

0.17321

−0.41375

0.04012

5.45E-24

rs7770628

LPA

Chr6: 160597142

C/T

0.1835

0.95012

0.70012

0.05102

5.09E-40

rs783147

PLG

Chr6: 160716958

G/A

0.4980

0.51151

−0.0018

0.04264

0.9664000000

rs9457778

–

Chr6: 159932259

C/T

0.3705

0.22391

0.09361

0.04241

0.0274770059

  1. SNP single nucleotide polymorphism, EA/OA effect allele/ other allele, MAF minor allele frequency, HWE(P) P value of Hardy-Weinberg equilibrium, SE standard error; sex and age were included into models for adjustment
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Lipids in Health and Disease

ISSN: 1476-511X