Effect of statins on post-contrast acute kidney injury: a multicenter retrospective observational study

Table 4 Univariate and multivariate logistic association for PC-AKI among patients with pre-operative statin therapy

	Univariable Analysis				Multivariable Analysis
	B	OR	95%CI	P	B	OR	95%CI	P
Male	−0.3	0.741	0.618–0.888	0.001	−0.403	0.668	0.541–0.826	<0.001
Age	0.027	1.028	1.019–1.037	<0.001	0.025	1.025	1.014–1.036	<0.001
Smoking	−0.224	0.799	0.629–1.016	0.067	−0.035	0.965	0.72–1.293	0.812
Drinking	−0.316	0.729	0.563–0.944	0.017	−0.009	0.991	0.734–1.339	0.954
Hypertension	0.207	1.229	1.016–1.487	0.033	0.064	1.066	0.861–1.318	0.559
Diabetes	0.413	1.511	1.251–1.825	<0.001	0.283	1.326	1.078–1.632	0.008
eGFR	−0.008	0.992	0.989–0.996	<0.001	0.004	1.004	0.999–1.009	0.097
Uric acid	0	1	0.999–1.001	0.901
LDL-C	0.003	1.003	0.913–1.102	0.945
CRP	0.012	1.013	1.009–1.016	<0.001	0.01	1.011	1.007–1.014	<0.001
LVEF	−0.025	0.975	0.969–0.981	<0.001	−0.026	0.974	0.967–0.981	<0.001
Excess volumes of CM	0.571	1.77	1.241–2.526	0.002	0.615	1.85	1.205–2.84	0.005
Iso-osmolar CM	0.001	1.001	0.831–1.204	0.996
Contrast Volume	0.001	1.001	1–1.002	0.119
Types of statins, Atorvastatin	0.083	1.087	0.929–1.271	0.297	0.051	1.052	0.887–1.249	0.558
Prior myocardial infarction history	0.164	1.178	0.64–2.168	0.598
Prior PCI history	0.075	1.077	0.754–1.54	0.682
CABG history	−0.946	0.388	0.051–2.973	0.362
Cardiac surgery history (except CABG)	0.814	2.257	0.693–7.353	0.177
Angiography combined with PCI	0.202	1.224	1.027–1.459	0.024
Multi vessel PCI	0.035	1.035	0.813–1.318	0.779
Total length of stents	−0.005	0.995	0.989–1.001	0.127

Abbreviations: PC-AKI post-contrast acute kidney injury, eGFR estimated glomerular filtration rate, LDL-C low-density lipoprotein cholesterol, CRP C-reactive protein, LVEF left ventricular ejection fractions, CM contrast medium, ACEI angiotensin converting enzyme inhibitors, PCI percutaneous coronary intervention, CABG coronary artery bypass grafting

ISSN: 1476-511X