High-density Lipoprotein Cholesterol Is Negatively Correlated with Bone Mineral Density and Has Potential Predictive Value for Bone Loss

Tang, Yuchen; Wang, Shenghong; Yi, Qiong; Xia, Yayi; Geng, Bin

doi:10.1186/s12944-021-01497-7

Lipids in Health and Disease

Table 3 Association between HDL-C and BMD stratified by age

From: High-density Lipoprotein Cholesterol Is Negatively Correlated with Bone Mineral Density and Has Potential Predictive Value for Bone Loss

		Model 1 β (95% CI) P value	Model 2 β (95% CI) P value	Model 3 β (95% CI) P value
Total femur BMD	20≤Aged<30	-0.0018 (-0.0023, -0.0013) <0.000001	-0.0008 (-0.0013, -0.0004) 0.000480	0.0001 (-0.0004, 0.0006) 0.598614
	30≤Aged<40	-0.0023 (-0.0027, -0.0018) <0.000001	-0.0016 (-0.0020, -0.0012) <0.000001	-0.0009 (-0.0013, -0.0004) 0.000185
	40≤Aged<50	-0.0019 (-0.0023, -0.0016) <0.000001	-0.0012 (-0.0015, -0.0008) <0.000001	-0.0002 (-0.0006, 0.0002) 0.281833
	50≤Aged<60	-0.0027 (-0.0032, -0.0021) <0.000001	-0.0018 (-0.0023, -0.0013) <0.000001	-0.0009 (-0.0014, -0.0003) 0.002075
	60≤Aged	-0.0029 (-0.0035, -0.0023) <0.000001	-0.0012 (-0.0017, -0.0007) 0.000012	-0.0003 (-0.0008, 0.0003) 0.327776
Femur neck BMD	20≤Aged<30	-0.0014 (-0.0018, -0.0009) <0.000001	-0.0007 (-0.0012, -0.0003) 0.001761	0.0002 (-0.0003, 0.0007) 0.335319
	30≤Aged<40	-0.0015 (-0.0019, -0.0011) <0.000001	-0.0013 (-0.0017, -0.0009) <0.000001	-0.0006 (-0.0011, -0.0002) 0.008064
	40≤Aged<50	-0.0013 (-0.0017, -0.0010) <0.000001	-0.0011 (-0.0014, -0.0007) <0.000001	-0.0003 (-0.0007, 0.0001) 0.149013
	50≤Aged<60	-0.0019 (-0.0023, -0.0015) <0.000001	-0.0015 (-0.0020, -0.0011) <0.000001	-0.0007 (-0.0012, -0.0001) 0.011229
	60≤Aged	-0.0020 (-0.0025, -0.0015) <0.000001	-0.0011 (-0.0016, -0.0006) 0.000009	-0.0003 (-0.0008, 0.0002) 0.195810
Trochanter BMD	20≤Aged<30	-0.0013 (-0.0018, -0.0009) <0.000001	-0.0005 (-0.0009, -0.0001) 0.008268	-0.0000 (-0.0005, 0.0004) 0.936942
	30≤Aged<40	-0.0015 (-0.0019, -0.0012) <0.000001	-0.0010 (-0.0014, -0.0006) <0.000001	-0.0006 (-0.0010, -0.0002) 0.007441
	40≤Aged<50	-0.0013 (-0.0017, -0.0010) <0.000001	-0.0007 (-0.0011, -0.0004) 0.000022	-0.0002 (-0.0005, 0.0002) 0.342789
	50≤Aged<60	-0.0020 (-0.0025, -0.0016) <0.000001	-0.0013 (-0.0018, -0.0008) <0.000001	-0.0007 (-0.0012, -0.0001) 0.013165
	60≤Aged	-0.0021 (-0.0026, -0.0016) <0.000001	-0.0006 (-0.0010, -0.0001) 0.011620	0.0000 (-0.0004, 0.0005) 0.930179
Intertrochanter BMD	20≤Aged<30	-0.0021 (-0.0027, -0.0016) <0.000001	-0.0010 (-0.0015, -0.0005) 0.000211	0.0001 (-0.0005, 0.0007) 0.697817
	30≤Aged<40	-0.0027 (-0.0032, -0.0022) <0.000001	-0.0019 (-0.0024, -0.0014) <0.000001	-0.0011 (-0.0016, -0.0006) 0.000067
	40≤Aged<50	-0.0023 (-0.0028, -0.0019) <0.000001	-0.0014 (-0.0018, -0.0009) <0.000001	-0.0002 (-0.0007, 0.0003) 0.365447
	50≤Aged<60	-0.0031 (-0.0037, -0.0025) <0.000001	-0.0021 (-0.0028, -0.0015) <0.000001	-0.0010 (-0.0017, -0.0004) 0.002512
	60≤Aged	-0.0035 (-0.0042, -0.0029) <0.000001	-0.0016 (-0.0022, -0.0009) 0.000002	-0.0005 (-0.0011, 0.0002) 0.160472
Total spine BMD	20≤Aged<30	-0.0005 (-0.0009, -0.0002) 0.006856	-0.0007 (-0.0011, -0.0003) 0.000465	-0.0001 (-0.0006, 0.0003) 0.540391
	30≤Aged<40	-0.0005 (-0.0009, -0.0001) 0.021297	-0.0009 (-0.0013, -0.0005) 0.000009	-0.0006 (-0.0010, -0.0001) 0.012320
	40≤Aged<50	-0.0004 (-0.0007, -0.0000) 0.037080	-0.0007 (-0.0011, -0.0003) 0.000666	-0.0001 (-0.0005, 0.0004) 0.795368
	50≤Aged<60	-0.0021 (-0.0026, -0.0016) <0.000001	-0.0019 (-0.0024, -0.0013) <0.000001	-0.0012 (-0.0018, -0.0005) 0.000354
	60≤Aged	-0.0024 (-0.0030, -0.0018) <0.000001	-0.0010 (-0.0016, -0.0004) 0.000661	-0.0004 (-0.0010, 0.0002) 0.171588
L1 BMD	20≤Aged<30	-0.0009 (-0.0013, -0.0004) 0.000068	-0.0006 (-0.0011, -0.0002) 0.003937	0.0001 (-0.0004, 0.0006) 0.734575
	30≤Aged<40	-0.0011 (-0.0015, -0.0007) <0.000001	-0.0010 (-0.0015, -0.0006) 0.000003	-0.0006 (-0.0011, -0.0001) 0.015966
	40≤Aged<50	-0.0011 (-0.0015, -0.0008) <0.000001	-0.0009 (-0.0013, -0.0005) 0.000013	-0.0002 (-0.0007, 0.0002) 0.357967
	50≤Aged<60	-0.0028 (-0.0033, -0.0022) <0.000001	-0.0022 (-0.0027, -0.0016) <0.000001	-0.0014 (-0.0020, -0.0008) 0.000018
	60≤Aged	-0.0033 (-0.0039, -0.0026) <0.000001	-0.0014 (-0.0020, -0.0009) <0.000001	-0.0007 (-0.0013, -0.0001) 0.020440
L2 BMD	20≤Aged<30	-0.0007 (-0.0011, -0.0003) 0.001453	-0.0008 (-0.0012, -0.0003) 0.000564	-0.0001 (-0.0006, 0.0003) 0.585766
	30≤Aged<40	-0.0007 (-0.0011, -0.0003) 0.001105	-0.0011 (-0.0015, -0.0006) 0.000003	-0.0007 (-0.0012, -0.0002) 0.005244
	40≤Aged<50	-0.0006 (-0.0010, -0.0002) 0.001416	-0.0008 (-0.0012, -0.0004) 0.000099	-0.0002 (-0.0007, 0.0002) 0.353490
	50≤Aged<60	-0.0023 (-0.0029, -0.0017) <0.000001	-0.0020 (-0.0026, -0.0014) <0.000001	-0.0014 (-0.0021, -0.0007) 0.000065
	60≤Aged	-0.0027 (-0.0033, -0.0021) <0.000001	-0.0011 (-0.0017, -0.0005) 0.000327	-0.0006 (-0.0012, 0.0001) 0.079934
L3 BMD	20≤Aged<30	-0.0003 (-0.0008, 0.0001) 0.106832	-0.0007 (-0.0012, -0.0003) 0.000815	-0.0002 (-0.0007, 0.0002) 0.312215
	30≤Aged<40	-0.0001 (-0.0005, 0.0003) 0.650876	-0.0009 (-0.0013, -0.0004) 0.000094	-0.0006 (-0.0011, -0.0001) 0.012140
	40≤Aged<50	0.0001 (-0.0003, 0.0005) 0.712982	-0.0005 (-0.0009, -0.0001) 0.027419	0.0001 (-0.0004, 0.0005) 0.761201
	50≤Aged<60	-0.0019 (-0.0025, -0.0013) <0.000001	-0.0019 (-0.0025, -0.0013) <0.000001	-0.0013 (-0.0020, -0.0006) 0.000341
	60≤Aged	-0.0022 (-0.0028, -0.0015) <0.000001	-0.0009 (-0.0015, -0.0002) 0.007370	-0.0002 (-0.0009, 0.0005) 0.588529
L4 BMD	20≤Aged<30	-0.0004 (-0.0008, 0.0000) 0.060890	-0.0008 (-0.0012, -0.0003) 0.000663	-0.0002 (-0.0007, 0.0003) 0.373641
	30≤Aged<40	-0.0001 (-0.0005, 0.0003) 0.679656	-0.0008 (-0.0012, -0.0003) 0.000554	-0.0004 (-0.0009, 0.0001) 0.086672
	40≤Aged<50	-0.0001 (-0.0005, 0.0003) 0.712879	-0.0006 (-0.0010, -0.0002) 0.006600	0.0001 (-0.0004, 0.0005) 0.810854
	50≤Aged<60	-0.0017 (-0.0022, -0.0011) <0.000001	-0.0016 (-0.0022, -0.0010) <0.000001	-0.0008 (-0.0014, -0.0001) 0.029822
	60≤Aged	-0.0019 (-0.0026, -0.0013) <0.000001	-0.0007 (-0.0014, -0.0001) 0.022931	-0.0003 (-0.0010, 0.0004) 0.399114

Model 1: no covariates were adjusted. Model 2: sex (male; female) and race/ethnicity (Mexican American; other Hispanic; non-Hispanic white; non-Hispanic black; other Races) were adjusted. Model 3: sex (male; female), race/ethnicity (Mexican American; other Hispanic; non-Hispanic white; non-Hispanic black; other races), education level (under high school; high school or equivalent; above high school), income to poverty ratio (quartile groups), BMI (obese, overweight, normal), smoking status (less than 100 cigarettes; greater than or equal to 100 cigarettes), alcohol consumption status (had at least 12 alcohol drinks past one year; have less than 12 alcohol drinks past one year), hypertension (yes; no), diabetes (yes; no; borderline), ALT (quartile groups), AST (quartile groups), total calcium (quartile groups), cholesterol (quartile groups), and C-reactive protein (quartile groups) were adjusted. HDL-C high-density lipoprotein cholesterol; BMD bone mineral density; ALT alanine aminotransferase; AST aspartate aminotransferase

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