High-density Lipoprotein Cholesterol Is Negatively Correlated with Bone Mineral Density and Has Potential Predictive Value for Bone Loss

Tang, Yuchen; Wang, Shenghong; Yi, Qiong; Xia, Yayi; Geng, Bin

doi:10.1186/s12944-021-01497-7

Lipids in Health and Disease

Table 4 Association between HDL-C and BMD stratified by sex

From: High-density Lipoprotein Cholesterol Is Negatively Correlated with Bone Mineral Density and Has Potential Predictive Value for Bone Loss

		Model 1 β (95% CI) P value	Model 2 β (95% CI) P value	Model 3 β (95% CI) P value
Total femur BMD	Male	-0.0011 (-0.0014, -0.0008) <0.000001	-0.0012 (-0.0015, -0.0009) <0.000001	-0.0002 (-0.0006, 0.0001) 0.116880
Total femur BMD	Female	-0.0015 (-0.0018, -0.0012) <0.000001	-0.0014 (-0.0017, -0.0012) <0.000001	-0.0005 (-0.0008, -0.0002) 0.000302
Femur neck BMD	Male	-0.0009 (-0.0012, -0.0006) <0.000001	-0.0010 (-0.0012, -0.0007) <0.000001	-0.0001 (-0.0004, 0.0002) 0.449640
Femur neck BMD	Female	-0.0015 (-0.0018, -0.0012) <0.000001	-0.0013 (-0.0016, -0.0011) <0.000001	-0.0005 (-0.0008, -0.0002) 0.000374
Trochanter BMD	Male	-0.0006 (-0.0008, -0.0003) 0.000047	-0.0007 (-0.0010, -0.0004) <0.000001	-0.0001 (-0.0004, 0.0002) 0.422344
Trochanter BMD	Female	-0.0010 (-0.0013, -0.0008) <0.000001	-0.0010 (-0.0012, -0.0008) <0.000001	-0.0004 (-0.0007, -0.0002) 0.001635
Intertrochanter BMD	Male	-0.0013 (-0.0017, -0.0010) <0.000001	-0.0015 (-0.0018, -0.0011) <0.000001	-0.0003 (-0.0007, 0.0000) 0.063777
Intertrochanter BMD	Female	-0.0018 (-0.0021, -0.0015) <0.000001	-0.0017 (-0.0020, -0.0014) <0.000001	-0.0006 (-0.0010, -0.0003) 0.000359
Total spine BMD	Male	-0.0005 (-0.0008, -0.0002) 0.002365	-0.0007 (-0.0010, -0.0004) 0.000003	-0.0001 (-0.0004, 0.0002) 0.520811
Total spine BMD	Female	-0.0013 (-0.0016, -0.0010) <0.000001	-0.0013 (-0.0015, -0.0010) <0.000001	-0.0007 (-0.0010, -0.0004) 0.000009
L1 BMD	Male	-0.0006 (-0.0009, -0.0003) 0.000064	-0.0008 (-0.0011, -0.0005) <0.000001	-0.0001 (-0.0004, 0.0003) 0.676951
L1 BMD	Female	-0.0016 (-0.0019, -0.0012) <0.000001	-0.0015 (-0.0018, -0.0012) <0.000001	-0.0008 (-0.0012, -0.0005) <0.000001
L2 BMD	Male	-0.0006 (-0.0009, -0.0003) 0.000265	-0.0008 (-0.0011, -0.0005) <0.000001	-0.0003 (-0.0006, 0.0001) 0.135526
L2 BMD	Female	-0.0014 (-0.0017, -0.0011) <0.000001	-0.0014 (-0.0017, -0.0011) <0.000001	-0.0008 (-0.0011, -0.0005) 0.000003
L3 BMD	Male	-0.0004 (-0.0007, -0.0000) 0.027488	-0.0006 (-0.0009, -0.0003) 0.000127	-0.0001 (-0.0004, 0.0002) 0.584406
L3 BMD	Female	-0.0012 (-0.0015, -0.0009) <0.000001	-0.0012 (-0.0015, -0.0009) <0.000001	-0.0007 (-0.0010, -0.0003) 0.000073
L4 BMD	Male	-0.0003 (-0.0006, 0.0000) 0.059045	-0.0006 (-0.0009, -0.0003) 0.000131	0.0000 (-0.0003, 0.0004) 0.962035
L4 BMD	Female	-0.0011 (-0.0014, -0.0007) <0.000001	-0.0011 (-0.0014, -0.0008) <0.000001	-0.0006 (-0.0009, -0.0002) 0.000690

Model 1: no covariates were adjusted. Model 2: age (20-29, 30-39, 40-49; 50-59; ≥60) and race/ethnicity (Mexican American; other Hispanic; non-Hispanic white; non-Hispanic black; other races) were adjusted. Model 3: age (20-29, 30-39, 40-49; 50-59; ≥60), race/ethnicity (Mexican American; other Hispanic; non-Hispanic white; non-Hispanic black; other races), education level (under high school; high school or equivalent; above high school), income to poverty ratio (quartile groups), BMI (obese, overweight, normal), smoking status (less than 100 cigarettes; greater than or equal to 100 cigarettes), alcohol consumption status (had at least 12 alcohol drinks past one year; have less than 12 alcohol drinks past one year), hypertension (yes; no), diabetes (yes; no; borderline), ALT (quartile groups), AST (quartile groups), total calcium (quartile groups), cholesterol (quartile groups), and C-reactive protein (quartile groups) were adjusted. HDL-C high-density lipoprotein cholesterol; BMD bone mineral density; ALT alanine aminotransferase; AST aspartate aminotransferase

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ISSN: 1476-511X

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