High-density Lipoprotein Cholesterol Is Negatively Correlated with Bone Mineral Density and Has Potential Predictive Value for Bone Loss

Tang, Yuchen; Wang, Shenghong; Yi, Qiong; Xia, Yayi; Geng, Bin

doi:10.1186/s12944-021-01497-7

Lipids in Health and Disease

Table 6 Association between HDL-C and BMD in females

From: High-density Lipoprotein Cholesterol Is Negatively Correlated with Bone Mineral Density and Has Potential Predictive Value for Bone Loss

		Model 1 β (95% CI) P value	Model 2 β (95% CI) P value	Model 3 β (95% CI) P value
Total femur BMD	20≤Aged<30	-0.0009 (-0.0014, -0.0003) 0.004084	-0.0009 (-0.0014, -0.0003) 0.003038	-0.0000 (-0.0007, 0.0006) 0.895165
	30≤Aged<40	-0.0016 (-0.0022, -0.0010) <0.000001	-0.0017 (-0.0023, -0.0011) <0.000001	-0.0010 (-0.0017, -0.0004) 0.002143
	40≤Aged<50	-0.0013 (-0.0018, -0.0008) <0.000001	-0.0013 (-0.0018, -0.0008) <0.000001	-0.0005 (-0.0010, 0.0001) 0.089961
	50≤Aged<60	-0.0020 (-0.0027, -0.0013) <0.000001	-0.0021 (-0.0028, -0.0014) <0.000001	-0.0010 (-0.0018, -0.0002) 0.013817
	60≤Aged	-0.0009 (-0.0018, -0.0001) 0.027771	-0.0011 (-0.0019, -0.0003) 0.007503	0.0000 (-0.0009, 0.0009) 0.965459
Femur neck BMD	20≤Aged<30	-0.0008 (-0.0014, -0.0002) 0.012262	-0.0008 (-0.0014, -0.0002) 0.008148	0.0002 (-0.0005, 0.0008) 0.613585
	30≤Aged<40	-0.0014 (-0.0020, -0.0008) 0.000005	-0.0015 (-0.0021, -0.0009) 0.000001	-0.0009 (-0.0016, -0.0003) 0.005558
	40≤Aged<50	-0.0012 (-0.0017, -0.0007) 0.000001	-0.0012 (-0.0017, -0.0007) <0.000001	-0.0004 (-0.0009, 0.0001) 0.127233
	50≤Aged<60	-0.0020 (-0.0027, -0.0014) <0.000001	-0.0021 (-0.0027, -0.0014) <0.000001	-0.0010 (-0.0018, -0.0003) 0.007700
	60≤Aged	-0.0009 (-0.0016, -0.0002) 0.018292	-0.0011 (-0.0018, -0.0004) 0.002431	-0.0001 (-0.0008, 0.0007) 0.863724
Trochanter BMD	20≤Aged<30	-0.0006 (-0.0011, -0.0001) 0.014098	-0.0006 (-0.0011, -0.0002) 0.010771	-0.0001 (-0.0007, 0.0004) 0.610232
	30≤Aged<40	-0.0011 (-0.0016, -0.0006) 0.000040	-0.0012 (-0.0017, -0.0006) 0.000016	-0.0007 (-0.0013, -0.0002) 0.012737
	40≤Aged<50	-0.0009 (-0.0013, -0.0004) 0.000066	-0.0009 (-0.0013, -0.0005) 0.000031	-0.0004 (-0.0008, 0.0001) 0.142166
	50≤Aged<60	-0.0014 (-0.0020, -0.0008) 0.000003	-0.0015 (-0.0021, -0.0009) 0.000001	-0.0007 (-0.0014, -0.0001) 0.030223
	60≤Aged	-0.0005 (-0.0012, 0.0002) 0.157187	-0.0007 (-0.0014, 0.0000) 0.057321	0.0002 (-0.0006, 0.0009) 0.642347
Intertrochanter BMD	20≤Aged<30	-0.0010 (-0.0017, -0.0004) 0.002288	-0.0010 (-0.0017, -0.0004) 0.001898	-0.0001 (-0.0009, 0.0006) 0.726263
	30≤Aged<40	-0.0019 (-0.0026, -0.0012) <0.000001	-0.0019 (-0.0026, -0.0012) <0.000001	-0.0012 (-0.0019, -0.0004) 0.002305
	40≤Aged<50	-0.0016 (-0.0022, -0.0010) <0.000001	-0.0016 (-0.0021, -0.0010) <0.000001	-0.0005 (-0.0012, 0.0001) 0.128057
	50≤Aged<60	-0.0024 (-0.0032, -0.0016) <0.000001	-0.0024 (-0.0033, -0.0016) <0.000001	-0.0012 (-0.0021, -0.0002) 0.016133
	60≤Aged	-0.0012 (-0.0023, -0.0002) 0.015602	-0.0014 (-0.0025, -0.0004) 0.004826	-0.0001 (-0.0011, 0.0010) 0.910292
Total spine BMD	20≤Aged<30	-0.0009 (-0.0015, -0.0004) 0.000976	-0.0010 (-0.0016, -0.0005) 0.000235	-0.0004 (-0.0010, 0.0002) 0.217578
	30≤Aged<40	-0.0011 (-0.0016, -0.0005) 0.000251	-0.0012 (-0.0017, -0.0006) 0.000042	-0.0010 (-0.0017, -0.0004) 0.001201
	40≤Aged<50	-0.0009 (-0.0014, -0.0004) 0.000360	-0.0011 (-0.0016, -0.0006) 0.000042	-0.0005 (-0.0011, 0.0001) 0.100247
	50≤Aged<60	-0.0020 (-0.0028, -0.0012) 0.000001	-0.0021 (-0.0029, -0.0013) <0.000001	-0.0012 (-0.0021, -0.0002) 0.016337
	60≤Aged	-0.0010 (-0.0019, -0.0001) 0.035685	-0.0013 (-0.0022, -0.0004) 0.004202	-0.0003 (-0.0013, 0.0006) 0.498599
L1 BMD	20≤Aged<30	-0.0009 (-0.0015, -0.0003) 0.004548	-0.0010 (-0.0015, -0.0004) 0.001433	-0.0002 (-0.0008, 0.0005) 0.640539
	30≤Aged<40	-0.0014 (-0.0020, -0.0008) 0.000012	-0.0015 (-0.0021, -0.0009) 0.000003	-0.0012 (-0.0019, -0.0005) 0.000460
	40≤Aged<50	-0.0012 (-0.0018, -0.0007) 0.000004	-0.0013 (-0.0019, -0.0008) <0.000001	-0.0007 (-0.0013, -0.0001) 0.015151
	50≤Aged<60	-0.0024 (-0.0032, -0.0016) <0.000001	-0.0025 (-0.0033, -0.0017) <0.000001	-0.0015 (-0.0025, -0.0006) 0.002117
	60≤Aged	-0.0014 (-0.0023, -0.0005) 0.002435	-0.0017 (-0.0026, -0.0008) 0.000241	-0.0006 (-0.0016, 0.0004) 0.234842
L2 BMD	20≤Aged<30	-0.0010 (-0.0015, -0.0004) 0.001734	-0.0010 (-0.0016, -0.0004) 0.000554	-0.0003 (-0.0009, 0.0004) 0.387438
	30≤Aged<40	-0.0013 (-0.0019, -0.0007) 0.000043	-0.0014 (-0.0020, -0.0008) 0.000007	-0.0012 (-0.0019, -0.0005) 0.000458
	40≤Aged<50	-0.0011 (-0.0016, -0.0005) 0.000098	-0.0012 (-0.0018, -0.0007) 0.000008	-0.0006 (-0.0012, 0.0000) 0.061290
	50≤Aged<60	-0.0020 (-0.0029, -0.0011) 0.000007	-0.0021 (-0.0030, -0.0013) 0.000002	-0.0012 (-0.0023, -0.0002) 0.022824
	60≤Aged	-0.0012 (-0.0022, -0.0003) 0.011340	-0.0016 (-0.0025, -0.0006) 0.001075	-0.0007 (-0.0017, 0.0003) 0.193459
L3 BMD	20≤Aged<30	-0.0009 (-0.0015, -0.0003) 0.001976	-0.0010 (-0.0016, -0.0005) 0.000412	-0.0004 (-0.0010, 0.0003) 0.255710
	30≤Aged<40	-0.0009 (-0.0015, -0.0003) 0.002536	-0.0011 (-0.0016, -0.0005) 0.000496	-0.0010 (-0.0017, -0.0003) 0.003036
	40≤Aged<50	-0.0007 (-0.0012, -0.0001) 0.016616	-0.0008 (-0.0013, -0.0003) 0.003383	-0.0003 (-0.0009, 0.0003) 0.335752
	50≤Aged<60	-0.0021 (-0.0030, -0.0013) 0.000002	-0.0022 (-0.0031, -0.0014) <0.000001	-0.0013 (-0.0024, -0.0003) 0.012235
	60≤Aged	-0.0010 (-0.0020, -0.0000) 0.042502	-0.0013 (-0.0023, -0.0004) 0.005913	-0.0003 (-0.0014, 0.0007) 0.548696
L4 BMD	20≤Aged<30	-0.0009 (-0.0015, -0.0004) 0.001136	-0.0010 (-0.0016, -0.0004) 0.000418	-0.0006 (-0.0013, 0.0000) 0.052108
	30≤Aged<40	-0.0008 (-0.0014, -0.0002) 0.009702	-0.0009 (-0.0015, -0.0003) 0.002916	-0.0008 (-0.0014, -0.0001) 0.018291
	40≤Aged<50	-0.0008 (-0.0014, -0.0003) 0.002988	-0.0010 (-0.0015, -0.0004) 0.000560	-0.0004 (-0.0010, 0.0002) 0.220609
	50≤Aged<60	-0.0016 (-0.0024, -0.0008) 0.000145	-0.0017 (-0.0025, -0.0009) 0.000041	-0.0008 (-0.0018, 0.0002) 0.108678
	60≤Aged	-0.0006 (-0.0016, 0.0004) 0.235832	-0.0009 (-0.0019, 0.0000) 0.053248	-0.0001 (-0.0011, 0.0010) 0.884132

Model 1: no covariates were adjusted. Model 2: race/ethnicity (Mexican American; other Hispanic; non-Hispanic white; non-Hispanic black; other races) were adjusted. Model 3: race/ethnicity (Mexican American; other Hispanic; non-Hispanic white; non-Hispanic black; other races), education level (under high school; high school or equivalent; above high school), income to poverty ratio (quartile groups), BMI (obese, overweight, normal), smoking status (less than 100 cigarettes; greater than or equal to 100 cigarettes), alcohol consumption status (had at least 12 alcohol drinks past one year; have less than 12 alcohol drinks past one year), hypertension (yes; no), diabetes (yes; no; borderline), ALT (quartile groups), AST (quartile groups), total calcium (quartile groups), cholesterol (quartile groups), and C-reactive protein (quartile groups) were adjusted. HDL-C high-density lipoprotein cholesterol; BMD bone mineral density; ALT alanine aminotransferase; AST aspartate aminotransferase

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