Fig. 1

Scheme showing EFA metabolism, interaction, and feedback regulation among immunocytes, cytokines, various bioactive lipids (BALs) and inflammation. 15-HETrE = 15-(S)-hydroxy-8,11,13-eicosatrienoic acid. M1 and M2 macrophages. Red lines indicate pro-inflammatory events; Green lines indicate anti-inflammatory events. For further details see the text