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Fig. 2 | Lipids in Health and Disease

Fig. 2

From: Molecular biochemical aspects of salt (sodium chloride) in inflammation and immune response with reference to hypertension and type 2 diabetes mellitus

Fig. 2

Scheme showing the effect of high sodium intake and potassium on the activity of desaturases, and formation of their metabolites. High sodium intake inhibits the activity of desaturases and the conversion of dietary LA and ALA to their respective metabolites. This results in decreased formation of vasodilator, and anti-inflammatory LXA4, resolvins, protectins and maresins due to the deficiency of their respective precursors and an increase in PGE2, LTs and TXs are pro-inflammatory in nature. Sodium enhances TH17 activation and enhances IL-17 formation and release whereas potassium inhibits these actions. IL-17 has pro-inflammatory actions and enhances ROS generation. For further details see text

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Lipids in Health and Disease

ISSN: 1476-511X