Fig. 1

The role of adiponectin in the pathogenesis of psoriasis. Adiponectin is secreted by fat cells and can act on keratinocytes and naive T cells. A decreased adiponectin content leads to increased pro-inflammatory cytokines and decreased anti-inflammatory cytokines [60]. Among these, TNF-α can further affect macrophages and myeloid dendritic cells, resulting in increased secretion of cytokines [60]. In addition, adiponectin increases the number of Vγ4γδT cells. In keratinocytes, adiponectin can activate the E2F1 gene through the AMPK pathway, and the decrease in adiponectin levels leads to reduced E2F1 gene activation, thereby promoting the proliferation of keratinocytes [61,62,63,64]. In addition, SIRT1 can interact with the FoxO family. Downregulation of SIRT1 leads to abnormal transcriptional regulation of genes related to cell proliferation, survival, apoptosis, and metabolism, resulting in abnormal cell apoptosis [65,66,67]. These changes interact with the infiltration of the inflammatory response, which leads to psoriasis