Table 1 Species of lipids significantly different between tumor and tumor adjacent tissues of CRC patients
From: Alterations in complex lipids in tumor tissue of patients with colorectal cancer
Name | Lipid class | Sub class | Tumor adjacent tissue | Tumor tissue | P |
|---|---|---|---|---|---|
Monoacylglycerols | |||||
 MG(18:1) | MG | Monoacylglycerols | 22.8 ± 1.34 | 16.7 ± 2.05 | 0.030 |
Diacylglycerols | |||||
 DG(29:2) | DG | Diacylglycerols | 119 ± 20.0 | 61.9 ± 6.27 | 0.014 |
 DG(32:0) | DG | Diacylglycerols | 38.5 ± 5.72 | 22.1 ± 3.63 | 0.021 |
 DG(33:1) | DG | Diacylglycerols | 20.4 ± 2.47 | 32.5 ± 3.04 | 0.005 |
 DG(33:3) | DG | Diacylglycerols | 782 ± 120 | 335 ± 55.2 | 0.008 |
 DG(33:4) | DG | Diacylglycerols | 379 ± 55.4 | 206 ± 29.3 | 0.019 |
 DG(33:5) | DG | Diacylglycerols | 28.0 ± 5.96 | 12.7 ± 2.51 | 0.022 |
 DG(35:4) | DG | Diacylglycerols | 438 ± 68.7 | 237 ± 16.6 | 0.010 |
 DG(35:5) | DG | Diacylglycerols | 609 ± 93.7 | 294 ± 35.7 | 0.014 |
 DG(35:6) | DG | Diacylglycerols | 15.2 ± 1.49 | 8.62 ± 0.75 | 0.002 |
 DG(36:0) | DG | Diacylglycerols | 82.3 ± 18.6 | 169 ± 20.7 | 0.006 |
 DG(44:5) | DG | Diacylglycerols | 29.0 ± 4.43 | 51.5 ± 6.43 | 0.041 |
Triacylglycerols | |||||
 TG(44:2) | TG | Triacylglycerols | 86.1 ± 25.1 | 32.8 ± 7.92 | 0.033 |
 TG(43:1) | TG | Triacylglycerols | 15.2 ± 1.80 | 7.73 ± 0.94 | 0.002 |
 TG(44:0) | TG | Triacylglycerols | 30.3 ± 4.80 | 15.8 ± 2.51 | 0.023 |
 TG(46:1) | TG | Triacylglycerols | 102 ± 20.4 | 26.9 ± 3.42 | 0.008 |
 TG(46:2) | TG | Triacylglycerols | 21.6 ± 4.08 | 9.76 ± 1.18 | 0.019 |
 TG(47:1) | TG | Triacylglycerols | 14.3 ± 1.93 | 6.79 ± 0.95 | 0.004 |
 TG(47:2) | TG | Triacylglycerols | 63.7 ± 14.7 | 27.7 ± 5.84 | 0.036 |
 TG(47:4) | TG | Triacylglycerols | 12.4 ± 1.63 | 9.11 ± 0.54 | 0.048 |
 TG(47:6) | TG | Triacylglycerols | 51.8 ± 9.95 | 28.0 ± 4.41 | 0.033 |
 TG(48:1) | TG | Triacylglycerols | 27.0 ± 4.70 | 13.1 ± 1.62 | 0.033 |
 TG(48:2) | TG | Triacylglycerols | 44.0 ± 7.78 | 19.5 ± 3.97 | 0.028 |
 TG(48:3) | TG | Triacylglycerols | 170 ± 29.9 | 71.0 ± 14.9 | 0.009 |
 TG(48:4) | TG | Triacylglycerols | 16.3 ± 1.24 | 10.0 ± 1.10 | 0.001 |
 TG(50:1) | TG | Triacylglycerols | 83.2 ± 12.2 | 39.8 ± 5.81 | 0.009 |
 TG(50:3) | TG | Triacylglycerols | 45.4 ± 6.63 | 21.7 ± 4.13 | 0.005 |
 TG(50:4) | TG | Triacylglycerols | 27.3 ± 4.56 | 14.5 ± 2.32 | 0.040 |
 TG(52:2) | TG | Triacylglycerols | 127 ± 20.0 | 74.9 ± 9.45 | 0.044 |
 TG(52:3) | TG | Triacylglycerols | 525 ± 102 | 283 ± 23.4 | 0.042 |
 TG(52:4) | TG | Triacylglycerols | 403 ± 49.6 | 177 ± 32.3 | 0.004 |
 TG(52:5) | TG | Triacylglycerols | 223 ± 39.2 | 98.8 ± 27.8 | 0.013 |
 TG(53:1) | TG | Triacylglycerols | 242 ± 41.4 | 127 ± 26.2 | 0.040 |
Phospholipids | |||||
 PC(26:0) | PC | Diacylglycerophosphocholines | 11.2 ± 2.05 | 25.9 ± 6.86 | 0.043 |
 PC(28:1) | PC | Diacylglycerophosphocholines | 11.5 ± 2.35 | 38.4 ± 7.76 | 0.004 |
 PC(30:0) | PC | Diacylglycerophosphocholines | 10.0 ± 2.38 | 37.1 ± 7.85 | 0.004 |
 PC(31:2) | PC | Diacylglycerophosphocholines | 22.3 ± 2.26 | 30.5 ± 3.36 | 0.043 |
 PC(31:4) | PC | Diacylglycerophosphocholines | 0.89 ± 0.21 | 4.87 ± 1.27 | 0.010 |
 PC(32:1) | PC | Diacylglycerophosphocholines | 43.2 ± 20.2 | 79.3 ± 22.8 | 0.040 |
 PC(34:1) | PC | Diacylglycerophosphocholines | 125 ± 45.1 | 272 ± 69.5 | 0.038 |
 PE(28:1) | PE | Diacylglycerophosphoethanolamines | 5.99 ± 1.28 | 18.7 ± 5.77 | 0.038 |
 PE(31:4) | PE | Diacylglycerophosphoethanolamines | 1.72 ± 0.76 | 7.74 ± 2.64 | 0.033 |
 PE(33:4) | PE | Diacylglycerophosphoethanolamines | 9.47 ± 2.05 | 40.7 ± 8.60 | 0.003 |
 PG(37:6) | PG | Diacylglycerophosphoglycerols | 1.31 ± 0.47 | 4.66 ± 1.72 | 0.032 |
 PS(16:0) | PS | Diacylglycerophosphoserines | 9.27 ± 1.94 | 21.5 ± 4.89 | 0.037 |
 PS(28:2) | PS | Diacylglycerophosphoserines | 9.83 ± 2.02 | 35.7 ± 8.67 | 0.011 |
 PA(P-39:1) | PA | 1-(1Z-alkenyl),2-acylglycerophosphates | 30.8 ± 2.43 | 43.4 ± 5.33 | 0.044 |
 PA(O-38:1) | PA | 1-alkyl,2-acylglycerophosphates | 64.3 ± 11.3 | 141 ± 26.6 | 0.008 |
 PC(O-36:4) | PC | 1-alkyl,2-acylglycerophosphocholines | 78.4 ± 13.8 | 165 ± 23.1 | 0.010 |
 PC(O-37:2) | PC | 1-alkyl,2-acylglycerophosphocholines | 78.3 ± 12.3 | 99.7 ± 10.3 | 0.034 |
Lysophospholipids | |||||
 LPC(24:0) | PC | Monoacylglycerophosphocholines | 10.8 ± 2.43 | 27.0 ± 6.86 | 0.023 |
 LPE(16:1) | PE | Monoacylglycerophosphoethanolamines | 5.66 ± 1.21 | 19.0 ± 4.69 | 0.013 |
 LPE(18:2) | PE | Monoacylglycerophosphoethanolamines | 23.3 ± 3.82 | 35.8 ± 4.55 | 0.036 |
 LPG(20:4) | PG | Monoacylglycerophosphoglycerols | 9.24 ± 1.95 | 22.2 ± 5.04 | 0.031 |
 LPG(21:0) | PG | Monoacylglycerophosphoglycerols | 6.52 ± 1.18 | 18.1 ± 5.11 | 0.045 |
 LPS(O-20:0) | PS | Monoalkylglycerophosphoserines | 40.3 ± 12.8 | 120 ± 31.0 | 0.037 |
Sphingolipids | |||||
 Cer(34:0) | Ceramides | N-acylsphinganines (dihydroceramides) | 88.3 ± 20.8 | 128 ± 14.3 | 0.041 |
 Cer(37:2) | Ceramides | N-acylsphingosines (ceramides) | 18.7 ± 0.81 | 28.7 ± 3.92 | 0.043 |
 Cer(38:1) | Ceramides | N-acylsphingosines (ceramides) | 23.9 ± 1.97 | 37.5 ± 4.21 | 0.042 |
 Cer(40:0) | Ceramides | N-acylsphinganines (dihydroceramides) | 26.2 ± 3.35 | 38.6 ± 5.27 | 0.030 |
 SM(34:2) | Phosphosphingolipids | Ceramide phosphocholines (sphingomyelins) | 71.8 ± 14.3 | 97.4 ± 8.37 | 0.047 |
 SM(39:2) | Phosphosphingolipids | Ceramide phosphocholines (sphingomyelins) | 146 ± 22.8 | 211 ± 10.0 | 0.041 |
 Sphingosine(14:2) | Sphingoid bases | Sphingoid base analogs | 6.85 ± 0.74 | 9.67 ± 1.13 | 0.033 |
 Sphingosine(18:3) | Sphingoid bases | Sphingoid base analogs | 131 ± 34.6 | 245 ± 30.3 | 0.011 |
Sterols | |||||
 22:3 Cholesteryl ester | Sterols | Steryl esters | 21.0 ± 3.33 | 35.9 ± 2.03 | 0.001 |
 3,5-cholestadien-7-one | Sterols | Cholesterol and derivatives | 18.3 ± 0.62 | 24.3 ± 2.20 | 0.038 |
 24,25-epoxy-cholesterol | Sterols | Cholesterol and derivatives | 19.4 ± 1.32 | 12.2 ± 1.47 | 0.001 |