Table 1 Main characteristics of the studies included in present meta-analysis
References (Author, Year) | Location | Study design | Method of RBP4 measurement | Clinical classification | Age in cases (years) | Female in cases (%) | BMI in cases (kg/m2) | RBP4 units | Cases | Controls | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
n | Mean ± SD | n | Mean ± SD | |||||||||
von Eynatten et al., 2007 [31] | Germany | Case-control | ELISA | CAD | 62.0 | 0.0 | 27.6 | μg/ml | 143 | 28.08 ± 8.54 | 96 | 31.38 ± 10.46 |
Mallat et al., 2008 [35] | France | Nest case-control | ELISA | CAD | 64.7 | 36.2 | 27.2 | mg/L | 1036 | 48.90 ± 16.80 | 1889 | 46.80 ± 14.30 |
Al-Daghri et al., 2009 [10] | Saudi Arabia | Case-control | ELISA | CAD + DM | 56.0 | 51.7 | 32.7 | mg/L | 29 | 33.40 ± 13.60 | 39 | 22.60 ± 9.50 |
Mahmoudi et al., 2012 [32] | Iran | Case-control | ELISA | CAD | 55.2 | 0.0 | 29.8 | μmol/L | 15 | 1.30 ± 0.29 | 15 | 1.24 ± 0.15 |
Sun et al., 2013 [33] | USA | Nest case-control | ELISA | CAD | 59.5 | 100.0 | 26.5 | μg/ml | 468 | 97.91 ± 43.72 | 472 | 94.56 ± 43.57 |
Cubedo et al., 2014 [12] | Spain | Case-control | ELISA | AMI | NA | 0.0 | NA | μg/ml | 68 | 32.00 ± 10.72 | 132 | 39.70 ± 10.34 |
Lambadiari et al., 2014 [7] | Greece | Case-control | ELISA | CAD | 64.0 | 11.8 | 28.9 | mg/L | 305 | 39.29 ± 11.72 | 91 | 24.83 ± 11.27 |
Li et al., 2014 [34] | China | Case-control | ELISA | CAD | 63.7 | 36.7 | 23.0 | μg/ml | 30 | 17.66 ± 15.32 | 30 | 17.49 ± 24.45 |
– | – | – | – | CAD + HIns | 63.7 | 41.4 | 25.0 | μg/ml | 29 | 26.67 ± 29.71 | – | – |
Liu et al., 2015 [8] | China | Prospective | ELISA | Stable CAD | NA | 100.0 | NA | μg/ml | 201 | 39.31 ± 15.12 | 225 | 25.57 ± 6.59 |
Guan et al., 2016 [11] | China | Case-control | ELISA | CAD | 63.7 | 45.7 | NA | mg/L | 35 | 18.39 ± 6.61 | 35 | 16.54 ± 4.34 |
– | – | – | – | CAD + HIns | 63.6 | 45.2 | NA | mg/L | 31 | 27.36 ± 8.32 | – | – |
Wang et al., 2018 [15] | China | Case-control | ELISA | CAD | 63.7 | 39.8 | 24.2 | μg/ml | 440 | 28.99 ± 10.87 | 218 | 31.44 ± 9.96 |
Liu et al., 2019 [14] | China | Case-control | ELISA | CAD | 60.5 | 25.0 | 25.5 | ng/ml | 180 | 5.70 ± 1.80 | 79 | 3.60 ± 2.40 |
Sun et al., 2019 [9] | China | Case-control | ELISA | SCH + CAD | 64.4 | 53.8 | 25.0 | μg/ml | 148 | 58.29 ± 13.86 | 102 | 35.07 ± 10.44 |
Pan et al., 2020 [13] | China | Case-control | ELISA | AMI | NA | NA | NA | ng/ml | 150 | 35.99 ± 20.34 | 75 | 44.67 ± 29.63 |
Si et al., 2020 [36] | China | Case-control | ELISA | CAD | 57.0 | 26.4 | 25.5 | ng/ml | 163 | 5.57 ± 2.57 | 77 | 4.89 ± 2.70 |