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Table 3 Predictors of VS-HTG, ranked by odds ratio

From: Incidence, predictors and patterns of care of patients with very severe hypertriglyceridemia in Ontario, Canada: a population-based cohort study

 

Univariable analysis

Multivariable analysis

Odds Ratio

LCL

UCL

P-value

Odds Ratio

LCL

UCL

P-value

Diabetes

4.85

4.50

5.22

< 0.0001

5.38

4.93

5.88

< 0.0001

Sex

 Male

4.24

3.88

4.63

< 0.0001

3.83

3.50

4.18

< 0.0001

 Female

REF

REF

REF

 

REF

REF

REF

 

Alcohol

6.34

4.96

8.09

< 0.0001

2.47

1.90

3.19

< 0.0001

Chronic liver disease

2.42

2.11

2.77

< 0.0001

1.71

1.48

1.97

< 0.0001

HTN

1.55

1.44

1.67

< 0.0001

1.69

1.54

1.86

< 0.0001

Obesity

3.27

2.49

4.29

< 0.0001

1.49

1.13

1.98

0.0049

CKD

2.33

2.01

2.69

< 0.0001

1.39

1.19

1.63

< 0.0001

Income quintile

 1 - lowest

1.21

1.09

1.35

0.0005

1.09

0.98

1.22

0.1134

 2

1.06

0.95

1.18

0.3011

1.02

0.92

1.14

0.6747

 3

REF

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REF

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 4

0.74

0.66

0.84

< 0.0001

0.78

0.70

0.88

< 0.0001

 5 - highest

0.63

0.55

0.71

< 0.0001

0.72

0.63

0.81

< 0.0001

Age (per decade)

0.84

0.82

0.86

< 0.0001

0.64

0.62

0.66

< 0.0001

Charlson comorbidity indexa

 0

REF

REF

REF

 

REF

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REF

 

 1

2.98

2.66

3.34

< 0.0001

1.61

1.42

1.82

< 0.0001

 2

2.00

1.69

2.37

< 0.0001

1.26

1.05

1.50

0.0137

 3+

2.99

2.54

3.51

< 0.0001

1.15

0.95

1.38

0.1504

  1. Sample size is the full cohort (N = 6,745,375); Exposed (n = 2869); Unexposed (n = 6,742,506) All predictors were associated with the odds of having hypertriglyceridemia. Diabetes includes both type 1 and type 2
  2. Abbreviations: LCL lower confidence limit, UCL upper confidence limit, HTN hypertension, CKD chronic kidney disease, REF used as reference
  3. a Missing income (< 1%) was recoded as ‘3’. Missing charlson (~ 50%) was due to patients having no hospitalizations for relevant comorbidities found during the 5 year lookback period; they were recoded as ‘0’