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Fig. 2 | Lipids in Health and Disease

Fig. 2

From: Sirtuin3 rs28365927 functional variant confers to the high risk of non-alcoholic fatty liver disease in Chinese Han population

Fig. 2

Individual susceptibility genes were selected based on the idea of “two-hit theory” affecting individual susceptibility risk of NAFLD. Among them, 7 genes (MTTP, PEMT, FASN, PGC1β, ApoE, mTOR and SLC27A5) were related to “first hit”. 10 genes (PNPLA3, Sirtuin3, CYP2E1, Fas, TLR4, TCF7L2, PPARG, IL6, STAT2 and HIF3A) were associated with “second hit”. Abbreviations: PGC1β, peroxisome proliferator-activated receptor-γ coactivator-1β; FASN, fatty acid synthase; mTOR, mechanistic target of rapamycin; PEMT, phosphatidylethanolamine N-methyltransferase; MTTP, microsomal triglyceride transfer protein; SLC27A5, soluble carrier family 27 member A5; APOE, Apolipoprotein E; CYP2E1, cytochrome P450 2E1; PPARG, Peroxisome proliferator-activated receptor-γ; TCF7L2, transcription factor 7-like 2; HIF3A, Hypoxia Inducible Factor 3 Alpha Subunit; PNPLA3, patatin-like phospholipase domain containing 3; FAS, fas cell surface death receptor; SIRT3, Sirtuin3; IL-6, interleukin-6; STAT2, signal transducer and activator of transcription 2; TLR4, toll like receptor 4

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