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Fig. 5 | Lipids in Health and Disease

Fig. 5

From: Sirtuin3 rs28365927 functional variant confers to the high risk of non-alcoholic fatty liver disease in Chinese Han population

Fig. 5

The potential mechanism pathway of SIRT3 rs28365927 to increase the risk of NAFLD. Sirtuin3 rs28365927 may leads to the production of reactive oxygen species (ROS) by decreasing the activity of MRC, inactivating the ERK-CREB pathway and reducing the activity of MTP/LCAD/SOD2, and the production of ROS leads to the death of liver cells, which in turn leads to an increase in serum ALT levels [2, 23,24,25,26, 34,35,36,37]. Abbreviations: SIRT3, Sirtuin3; MRC,mitochondrial respiratory chain; ROS, reactive oxygen species; ERK,extracellular signal regulated kinase; CREB,the cAMP response element binding protein; Bnip3,BCL2 interacting protein 3; MTP,mitochondrial trifunctional protein; LCAD,long chain acyl coa dehydrogenase; SOD2,superoxide dismutase 2; NAFLD,Non-alcoholic fatty liver disease

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Lipids in Health and Disease

ISSN: 1476-511X