Table 1 Allele and genotype distribution of 17 SNPs in NAFLD patients and Non-NALFD patients
Gene name | SNP | Nucleotide change | Protein change | Variant allele | Wild-type allele | P-value | Homozygote genotype | Heterozygote genotype | Wild-type genotype | P-value for HWE test (NAFLD/Non-NAFLD) | P-value |
|---|---|---|---|---|---|---|---|---|---|---|---|
NAFLD/Non -NAFLD(%) | NAFLD/Non -NAFLD(%) | NAFLD/Non -NAFLD(%) | NAFLD/Non -NAFLD(%) | NAFLD/Non -NAFLD(%) | |||||||
PPARG | rs1801282 | g.12393125C > G | Pro12Ala | 4.0%/3.5% | 96.0%/96.5% | 0.659 | −/− | 8.0%/7.1% | 92.0%/92.9% | 0.479/0.473 | 0.652 |
STAT2 | rs2066811 | g.56742997 T > C | p.Ile464Val | −/− | 100.0%/100.0% | – | −/− | −/− | 100.0%/100.0% | −/− | – |
IL6 | rs2069849 | g.22771156C > T | p.Phe201Leu | 0.4%/0.1% | 99.6%/99.9% | 0.401 | −/− | 0.7%/0.3% | 99.3%/99.7% | 0.953/0.980 | 0.401 |
FASN | rs2228305 | g.80042792C > T | p.Val1483Ile | 0.9%/0.3% | 99.1%/99.7% | 0.124 | 0.7%/− | 0.4%/0.5% | 98.9%/99.5% | 0..000/0.959 | 0.248 |
MTTP | rs2306985 | g.100516022C > G | p.His297Gln | 67.1%/65.3% | 32.9%/34.7% | 0.477 | 44.8%/43.3% | 44.8%/43.9% | 10.5%/12.8% | 0.810/0.526 | 0.657 |
SIRT3 | rs28365927 | g.236091G > A | p.Arg80Trp | 14.3%/11.4% | 85.7%/88.6% | 0.127 | 1.1%/2.1% | 26.4%/18.7% | 72.5%/79.2% | 0.178/0.126 | 0.040 |
mTOR | rs28990992 | g.11249789G > C | p.Glu51Asp | 4.4%、4.4% | 95.6%/95.6% | 0.963 | 0.7%/0.8% | 7.4%/7.3% | 91.9%/91.9% | 0.040/0.007 | 0.992 |
Fas | rs3218619 | g.90762801G > A | p.Ala16Thr | −/− | 100.0%/100.0% | – | −/− | −/− | 100.0%/100.0% | −/− | – |
SLC27A5 | rs35350976 | g.59023174A > G | p.Met50Thr | 5.6%/4.5% | 94.4%/95.5% | 0.381 | 0.4%/0.3% | 10.5%/8.6% | 89.1%/91.2% | 0.883/0.787 | 0.682 |
ApoE | rs440446 | g.45409167C > G | p.Asn14Lys | 42.0%/39.1% | 58.0%/60.9% | 0.279 | 17.7%/14.9% | 48.6%/48.4% | 33.7%/36.8% | 0.960/0.754 | 0.537 |
TLR4 | rs4986790 | g.120475302A > G | p.Asp299Gly | −/0.1% | 100.0%/99.9% | 0.747 | −/− | −/0.3% | 100.0%/99.7% | 1.000/0.980 | 0.387 |
CYP2E1 | rs6413419 | g.135345675G > T | p.Val179Phe | −/− | 100.0%/100.0% | – | −/− | −/− | 100.0%/100.0% | −/− | – |
PNPLA3 | rs738409 | g.44324727C > G | p.Ile148Met | 38.5%/37.9% | 61.5%/62.1% | 0.827 | 18.4%/13.9% | 40.3%/48.0% | 41.3%/38.1% | 0.012/0.695 | 0.097 |
PGC1β | rs7732671 | g.149212243G > C | p.Ala203Pro | 5.9%/5.0% | 94.1%/95.0% | 0.439 | −/0.5% | 11.8%/8.9% | 88.2%/90.6% | 0.286/0.252 | 0.219 |
TCF7L2 | rs77961654 | g.114925369C > A | p.Pro200Thr | 26.4%/25.1% | 73.6%/74.9% | 0.594 | 8.6%/7.6% | 35.7%/35.0% | 55.7%/57.4% | 0.172/0.173 | 0.870 |
PEMT | rs7946 | g.17409560C > T | p.Val212Met | 17.4%/17.6% | 82.6%/82.4% | 0.918 | 3.5%/3.2% | 27.7%/28.8% | 68.8%/68.0% | 0.538/0.915 | 0.923 |
HIF3A | rs3764609 | g.46823702A > G | p.Gln274Arg | 40.0%/37.2% | 60.0%/62.8% | 0.287 | 16.8%/13.4% | 46.5%/47.6% | 36.7%/39.0% | 0.595/0.696 | 0.456 |