Sirtuin3 rs28365927 functional variant confers to the high risk of non-alcoholic fatty liver disease in Chinese Han population

Table 2 Clinical Characteristics of Patients with NAFLD and Non-NAFLD in study population^a

Characteristics	Non-NAFLD patients (n = 387)	NAFLD patients (n = 292)	P Value
Age, y	41.97 ± 12.17	48.89 ± 11.57	0.000
Gender,Male /Female	134/251	177/114	0.000
ALT, U/L	19.37 ± 14.17	33.24 ± 29.92	0.000
AST, U/L	22.59 ± 9.59	29.24 ± 14.47	0.000
FBG, mmol/L	5.11 ± 1.42	5.55 ± 1.63	0.000
LDL-C, mmol/L	2.81 ± 0.80	3.12 ± 0.83	0.000
TG, mmol/L	1.34 ± 0.92	2.51 ± 1.84	0.000
TC, mmol/L	4.88 ± 0.97	5.14 ± 1.07	0.001
HDL-C, mmol/L	1.58 ± 0.38	1.27 ± 0.33	0.000
BMI, kg/m²	22.13 ± 2.56	26.25 ± 2.55	0.000
SBP, mmHg	116.01 ± 17.21	123.95 ± 19.82	0.000
DBP, mmHg	73.43 ± 11.87	84.07 ± 15.61	0.000
WC, cm	73.65 ± 8.12	85.40 ± 8.29	0.000
HC, cm	89.62 ± 6.00	95.28 ± 6.68	0.000
TP,g/L	73.75 ± 3.84	72.51 ± 4.93	0.000
Albumin,g/L	45.97 ± 3.09	45.03 ± 4.54	0.003
Globulin,g/L	27.73 ± 3.38	27.88 ± 5.76	0.667
A/G	1.69 ± 0.24	1.67 ± 0.33	0.444
TBIL, umol/L	12.87 ± 8.14	12.80 ± 6.35	0.915
DBIL, umol/L	5.22 ± 2.30	5.47 ± 3.47	0.260
TBA,umol/L	3.55 ± 7.09	4.49 ± 4.98	0.232

Abbreviations: BMI Body Mass Index, SBP systemic blood pressure, DBP diastolic blood pressure, WC Waist circumference, HP Hip circumference, TP Total Protein, A/G the ratio of albumin to globulin, TBIL total bilirubin, DBIL direct bilirubin, TBA total bile acid, ALT glutamic-pyruvic transaminase, AST glutamic oxalacetic transaminase, FBG fasting blood-glucose, LDL-C low density lipoprotein cholesterin, TG triglyceride, TC total cholesterol, HDL-C high density lipoprotein cholesterol, NAFLD nonalcoholic fatty liver disease
^aValues are expressed as mean ± SD or counts and compared by Student’s t-test if the data is normally distributed, otherwise Mann-Whitney U test is used, except for gender that p value stands for statistical significance using Chi-square test. P-value<0.05 considered as statistically significant (in bold)

ISSN: 1476-511X