Skip to main content

Table 4 Association of rs28365927 with NAFLD based on four genetic models in the Study populationa

From: Sirtuin3 rs28365927 functional variant confers to the high risk of non-alcoholic fatty liver disease in Chinese Han population

 

Unadjusted

 

Adjusteda

 

Adjustedb

 

OR (95% CI)

P Value

OR(95% CI)

P Value

OR(95% CI)

P Value

unmatched

GA + AA vs GG

1.489(1.034–2.145)

0.032

1.532(1.026–2.287)

0.037

1.976(1.088–3.588)

0.025

AA vs GA + GG

0.491(0.129–1.868)

0.297

0.486(0.109–2.163)

0.343

1.077(0.123–9.433)

0.947

A vs G

1.286(0.925–1.786)

0.135

1.327(0.925–1.905)

0.124

1.555(0.909–2.661)

0.107

GG

1

0.042

1

0.052

1

0.204

GA

1.552(1.066–2.260)

0.022

1.600(1.061–2.415)

0.025

1.744(0.946–3.215)

0.075

AA

0.542(0.142–2.068)

0.370

0.541(0.121–2.417)

0.421

1.225(0.138–10.897)

0.855

matched

GA + AA vs GG

1.662(1.054–2.619)

0.029

1.655(1.048–2.612)

0.031

1.838(1.011–3.341)

0.046

AA vs GA + GG

1.005(0.201–5.034)

0.995

1.004(0.199–5.053)

0.996

1.820(0.241–13.761)

0.562

A vs G

1.523(1.007–2.304)

0.046

1.516(1.001–2.295)

0.049

1.716(1.001–2.942)

0.050

GG

1

0.082

1

0.087

1

0.135

GA

1.705(1.069–2.721)

0.025

1.697(1.062–2.712)

0.027

1.822(0.987–3.363)

0.055

AA

1.127(0.224–5.662)

0.885

1.126(0.223–5.687)

0.885

2.084(0.273–15.935)

0.479

  1. Abbreviations: OR odds ratio, P-value<0.05 considered as statistically significant (in bold);four logistic regression models (dominant:heterozygotes and variant homozygotes vs. wild homozygotes; recessive:variant homozygotes vs. wild homozygotes and heterozygotes; additive: variant allele vs. wild allele; genotypic: heterozygotes or variant homozygotes vs. wild homozygotes) were used to analyze the SNPs
  2. aBinary logistic regression model was adjusted for age and gender
  3. bBinary logistic regression model was adjusted for age,gender and body mass index