| |
Unadjusted
| |
Adjusteda
| |
Adjustedb
| |
|---|
|
OR (95% CI)
|
P Value
|
OR(95% CI)
|
P Value
|
OR(95% CI)
|
P Value
|
|---|
|
unmatched
|
|
GA + AA vs GG
|
1.489(1.034–2.145)
|
0.032
|
1.532(1.026–2.287)
|
0.037
|
1.976(1.088–3.588)
|
0.025
|
|
AA vs GA + GG
|
0.491(0.129–1.868)
|
0.297
|
0.486(0.109–2.163)
|
0.343
|
1.077(0.123–9.433)
|
0.947
|
|
A vs G
|
1.286(0.925–1.786)
|
0.135
|
1.327(0.925–1.905)
|
0.124
|
1.555(0.909–2.661)
|
0.107
|
|
GG
|
1
|
0.042
|
1
|
0.052
|
1
|
0.204
|
|
GA
|
1.552(1.066–2.260)
|
0.022
|
1.600(1.061–2.415)
|
0.025
|
1.744(0.946–3.215)
|
0.075
|
|
AA
|
0.542(0.142–2.068)
|
0.370
|
0.541(0.121–2.417)
|
0.421
|
1.225(0.138–10.897)
|
0.855
|
|
matched
|
|
GA + AA vs GG
|
1.662(1.054–2.619)
|
0.029
|
1.655(1.048–2.612)
|
0.031
|
1.838(1.011–3.341)
|
0.046
|
|
AA vs GA + GG
|
1.005(0.201–5.034)
|
0.995
|
1.004(0.199–5.053)
|
0.996
|
1.820(0.241–13.761)
|
0.562
|
|
A vs G
|
1.523(1.007–2.304)
|
0.046
|
1.516(1.001–2.295)
|
0.049
|
1.716(1.001–2.942)
|
0.050
|
|
GG
|
1
|
0.082
|
1
|
0.087
|
1
|
0.135
|
|
GA
|
1.705(1.069–2.721)
|
0.025
|
1.697(1.062–2.712)
|
0.027
|
1.822(0.987–3.363)
|
0.055
|
|
AA
|
1.127(0.224–5.662)
|
0.885
|
1.126(0.223–5.687)
|
0.885
|
2.084(0.273–15.935)
|
0.479
|
- Abbreviations: OR odds ratio, P-value<0.05 considered as statistically significant (in bold);four logistic regression models (dominant:heterozygotes and variant homozygotes vs. wild homozygotes; recessive:variant homozygotes vs. wild homozygotes and heterozygotes; additive: variant allele vs. wild allele; genotypic: heterozygotes or variant homozygotes vs. wild homozygotes) were used to analyze the SNPs
- aBinary logistic regression model was adjusted for age and gender
- bBinary logistic regression model was adjusted for age,gender and body mass index
