Sirtuin3 rs28365927 functional variant confers to the high risk of non-alcoholic fatty liver disease in Chinese Han population

Table 5 Clinical Characteristics of SIRT3 rs28365927 A Carriers(AA+AG) and Non-Carriers(GG) in the NAFLD Population^a

Characteristic	Carriers (n = 78)	Non-Carriers (n = 206)	P Value
Age, y	49.38 ± 11.89	48.78 ± 11.47	0.834
Gender,Male /Female	48/30	123/82	0.813
BMI, kg/m²	25.80 ± 2.78	26.40 ± 2.47	0.123
SBP, mmHg	121.72 ± 18.15	124.45 ± 20.35	0.322
DBP, mmHg	82.28 ± 14.85	84.73 ± 15.96	0.623
WC, cm	85.02 ± 8.70	85.64 ± 8.21	0.747
HP, cm	94.43 ± 6.29	95.65 ± 6.88	0.220
TP,g/L	72.48 ± 5.33	72.42 ± 4.81	0.434
Albumin,g/L	45.00 ± 4.49	45.00 ± 4.63	0.529
Globulin,g/L	27.54 ± 3.08	27.72 ± 5.34	0.636
A/G	1.70 ± 0.50	1.66 ± 0.25	0.765
TBIL, umol/L	13.74 ± 6.20	12.37 ± 6.40	0.022
DBIL, umol/L	6.01 ± 3.41	5.24 ± 3.52	0.021
TBA,umol/L	4.66 ± 5.13	4.45 ± 5.00	0.959
ALT, U/L	38.64 ± 43.94	27.31 ± 12.92	0.012
AST, U/L	30.82 ± 14.47	28.62 ± 14.66	0.250
FBG, mmol/L	5.54 ± 1.41	5.56 ± 1.74	0.389
LDL-C, mmol/L	3.04 ± 0.80	3.160.86	0.314
TG, mmol/L	2.17 ± 0.96	2.66 ± 2.10	0.318
TC, mmol/L	5.11 ± 0.89	5.17 ± 1.13	0.968
HDL-C, mmol/L	1.26 ± 0.30	1.26 ± 0.33	0.779

Abbreviations: BMI Body Mass Index, SBP systemic blood pressure, DBP diastolic blood pressure, WC Waist circumference, HP Hip circumference, TP Total Protein, A/G the ratio of albumin to globulin, TBIL total bilirubin, DBIL direct bilirubin, TBA total bile acid, ALT glutamic-pyruvic transaminase, AST glutamic oxalacetic transaminase, FBG fasting blood-glucose, LDL-C low density lipoprotein cholesterin, TG triglyceride, TC total cholesterol, HDL-C high density lipoprotein cholesterol, NAFLD nonalcoholic fatty liver disease
^aValues are expressed as mean ± SD and compared by Student’s t-test if the data is normally distributed, otherwise Mann-Whitney U test is used, except for gender that p value stands for statistical significance using Chi-square test. P-value<0.05 considered as statistically significant (in bold)

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