Sirtuin3 rs28365927 functional variant confers to the high risk of non-alcoholic fatty liver disease in Chinese Han population

Table 6 Significant associations between rs28365927 A Carriers(AA+AG) and Clinical Characteristics in a covariate adjusted linear regression analysis in the NAFLD Population^a

Characteristic	β-coefficient	STAT	P Value
BMI, kg/m²	−0.569	−1.506	0.133
SBP, mmHg	−3.082	−1.117	0.265
DBP, mmHg	−2.583	−1.196	0.233
WC, cm	−0.440	−0.373	0.709
HP, cm	−1.148	−1.196	0.233
TP,g/L	0.116	0.185	0.853
Albumin,g/L	0.060	0.106	0.915
Globulin,g/L	−0.424	−0.558	0.577
A/G	0.039	0.897	0.370
TBIL, umol/L	1.220	1.511	0.132
DBIL, umol/L	0.703	1.542	0.124
TBA,umol/L	0.154	0.156	0.876
ALT, U/L	7.632	2.013	0.045
AST, U/L	2.446	0.857	0.393
FBG, mmol/L	0.025	0.130	0.897
LDL-C, mmol/L	−0.101	−0.903	0.367
TG, mmol/L	−0.437	−1.968	0.050
TC, mmol/L	−0.019	−0.135	0.893
HDL-C, mmol/L	−0.003	−0.080	0.936

Abbreviations: BMI Body Mass Index, SBP systemic blood pressure, DBP diastolic blood pressure, WC Waist circumference, HP Hip circumference, TP Total Protein, A/G the ratio of albumin to globulin, TBIL total bilirubin, DBIL direct bilirubin, TBA total bile acid, ALT glutamic-pyruvic transaminase, AST glutamic oxalacetic transaminase, FBG fasting blood-glucose, LDL-C low density lipoprotein cholesterin, TG triglyceride, TC total cholesterol, HDL-C high density lipoprotein cholesterol, NAFLD nonalcoholic fatty liver disease
^aβ-coefficient: estimated quantitative effect of rs28365927 A Carriers on a phenotype of NAFLD, STAT: T statistic, P: level of statistical significance of the covariate(age and gender) adjusted linear regression analysis. P-value<0.05 considered as statistically significant (in bold)

ISSN: 1476-511X