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Table 1 Weights and biochemical variables of the animal subjects in the studied groups

From: Metformin ameliorates maternal high-fat diet-induced maternal dysbiosis and fetal liver apoptosis

 

BW (gm)

Liver (gm)

Liver / BW

Mother net weight (gm)

Fetal weight (gm)

Blood glucose (mg/dL)

AST (U/L)

ALT (U/L)

T-Cholesterol (mg/dL)

NCD

325.6 ± 6.4 # †

9.59 ± 0.4 #

0.03 ± 0.001 †

286.2 ± 5.5 # †

2.75 ± 0.26

68.83 ± 3.20

85.9 ± 9.3

34.3 ± 1.1 †

61.7 ± 5.4

HFD

395.3 ± 10.9 *†

12.87 ± 0.5 *†

0.03 ± 0.001 †

351.0 ± 11.7 *†

3.24 ± 0.39

77. 88 ± 5.54 †

98.7 ± 8.2

34.7 ± 2.1 †

60.5 ± 7.1

HFMf

293.2 ± 9.1 *#

10.78 ± 0.6 #

0.04 ± 0.002 *#

260.1 ± 8.8 *#

2.56 ± 0.27

61.14 ± 3.13 #

112.3 ± 16.6

28.6 ± 1.2 *#

50.0 ± 6.7

  1. NCD normal-chow diet, HFD high-fat diet, HFMf high-fat diet co-treated with metformin during pregnancy, BW body weight of maternal rats, Liver liver weight of the maternal rats, Mother net weight calculated by subtracting placental and fetal weights from body weight of maternal rats, Blood glucose serum glucose level in the maternal rats, AST aspartate transaminase, ALT alanine aminotransferase, T-Cholesterol serum total cholesterol of maternal rats
  2. *p < 0.05 compared with the NCD group
  3. #p < 0.05 compared with the HFD group
  4. †p < 0.05 compared with the HFMf group; mean ± standard error
  5. The data were presented as mean ± standard error