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Table 2 Associated factors with malignant IPMNs

From: Low high-density lipoprotein cholesterol levels are associated with malignant intraductal papillary mucinous neoplasms: A multicenter study

 

Training group (center 1 and center 2)

Validation group (center 3)

 

variables

Univariable

 

Multivariable

   

Multivariable

   

OR (95 %CI)

P

Model 1

P

Model 2

P

Model 1

P

Model 2

P

  

OR (95 %CI)

 

OR (95 %CI)

 

OR (95 %CI)

 

OR (95 %CI)

 

Mural nodule (yes vs. no )

9.56

(2.92–31.30)

< 0.01

15.14

(3.10–74.07)

< 0.01

14.51

(3.05–69.02)

< 0.01

16.11

(2.78–93.5)

< 0.01

25.2

(3.43–185.4)

< 0.01

Duct (cm)

18.0

(5.84–55.52)

< 0.01

10.45

(1.78–61.17)

0.02

11.61

(1.88–71.65)

0.02

15.4

(2.36–89.6)

< 0.01

18.76

(3.32–165.3)

< 0.01

Size (cm)

1.09

(0.91–1.30)

0.42

0.99

(0.79–1.23)

0.97

0.95

(0.76–1.19)

0.71

1.07

(0.86–1.28)

0.68

1.06

(0.86–1.31)

0.70

Type

 

< 0.01

 

0.11

 

0.10

 

< 0.01

 

< 0.01

MD + MT

1

 

1

 

1

 

1

 

1

 

Branch-duct

0.15

(0.07–0.34)

 

0.39

(0.10–1.53)

 

0.38

(0.09–1.53)

 

0.21

(0.10–0.37)

 

0.16

(0.09–0.28)

 

Location

 

0.11

 

0.28

 

0.38

 

0.49

 

0.53

Head-neck

1

 

1

 

1

 

1

 

1

 

Body-Tail

0.54

(0.26–1.15)

 

0.57

(0.22–1.50)

 

0.62

(0.23–1.63)

 

0.47

(0.18–1.21)

 

0.50

(0.20–1.27)

 

HDL-c (< 0.7 vs. ≥ 0.7 mmol/L)

8.93

(1.78–44.80)

< 0.01

17.92

(2.40–134.17)

< 0.01

20.56

(2.58–163.64)

< 0.01

6.63

(1.14–38.47)

0.02

6.66

(1.08–41.06)

0.02

  1. Model 1 was adjusted with body mass index, age and gender; Model 2 was additionally adjusted with pancreatitis, low density lipoprotein levels and diabetes
  2. HDL-c: high-density lipoprotein cholesterol; MD: main duct; MT: mixed type