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Table 2 Associated factors with malignant IPMNs

From: Low high-density lipoprotein cholesterol levels are associated with malignant intraductal papillary mucinous neoplasms: A multicenter study

  Training group (center 1 and center 2) Validation group (center 3)  
variables Univariable   Multivariable     Multivariable    
OR (95 %CI) P Model 1 P Model 2 P Model 1 P Model 2 P
   OR (95 %CI)   OR (95 %CI)   OR (95 %CI)   OR (95 %CI)  
Mural nodule (yes vs. no ) 9.56
(2.92–31.30)
< 0.01 15.14
(3.10–74.07)
< 0.01 14.51
(3.05–69.02)
< 0.01 16.11
(2.78–93.5)
< 0.01 25.2
(3.43–185.4)
< 0.01
Duct (cm) 18.0
(5.84–55.52)
< 0.01 10.45
(1.78–61.17)
0.02 11.61
(1.88–71.65)
0.02 15.4
(2.36–89.6)
< 0.01 18.76
(3.32–165.3)
< 0.01
Size (cm) 1.09
(0.91–1.30)
0.42 0.99
(0.79–1.23)
0.97 0.95
(0.76–1.19)
0.71 1.07
(0.86–1.28)
0.68 1.06
(0.86–1.31)
0.70
Type   < 0.01   0.11   0.10   < 0.01   < 0.01
MD + MT 1   1   1   1   1  
Branch-duct 0.15
(0.07–0.34)
  0.39
(0.10–1.53)
  0.38
(0.09–1.53)
  0.21
(0.10–0.37)
  0.16
(0.09–0.28)
 
Location   0.11   0.28   0.38   0.49   0.53
Head-neck 1   1   1   1   1  
Body-Tail 0.54
(0.26–1.15)
  0.57
(0.22–1.50)
  0.62
(0.23–1.63)
  0.47
(0.18–1.21)
  0.50
(0.20–1.27)
 
HDL-c (< 0.7 vs. ≥ 0.7 mmol/L) 8.93
(1.78–44.80)
< 0.01 17.92
(2.40–134.17)
< 0.01 20.56
(2.58–163.64)
< 0.01 6.63
(1.14–38.47)
0.02 6.66
(1.08–41.06)
0.02
  1. Model 1 was adjusted with body mass index, age and gender; Model 2 was additionally adjusted with pancreatitis, low density lipoprotein levels and diabetes
  2. HDL-c: high-density lipoprotein cholesterol; MD: main duct; MT: mixed type