Table 1 Characteristics of study cohorts
Variable | Population 1 (Development cohort) | Population 2 (Validation cohort 1) | Population 3 (Validation cohort 2, KNHANES 2017) | ||||||
|---|---|---|---|---|---|---|---|---|---|
Gender distribution | Total | Men | Women | Total | Men | Women | Total | Men | Women |
Number of subjects | 4562 | 2202 | 2360 | 2086 | 1016 | 1070 | 889 | 588 | 301 |
Age, years (median, IQR) | 55.7 (46.3–63.4) | 55.2 (45.9–62.7) | 56.3 (46.8–64.0) | 55.4 (46.3–63.8) | 53.9 (45.5–62.1) | 56.7 (47.6–65.7) | 53.3 (41.0–64.0) | 49.0 (39.0–60.0) | 58.0 (49.0–70.0) |
Lipid profile test result of all specimens (Number of tests) | 5198 | 2570 | 2628 | 2163 | 1062 | 1101 | 889 | 588 | 301 |
Total cholesterol, mg/dL, median (IQR) | 180 (153 to 209) | 176 (150 to 205) | 184 (157 to 212) | 177 (152 to 209) | 173.5 (148 to 205) | 180 (155 to 211) | 210 (183 to 239) | 209 (183 to 239) | 211 (184 to 240) |
HDL, mg/dL, median (IQR) | 52 (43 to 63) | 48 (40 to 57) | 57 (47 to 69) | 53 (44 to 65) | 49 (41 to 59) | 58 (48 to 70) | 41 (36 to 47) | 40 (36 to 46) | 42 (37 to 49) |
TG, mg/dL, median (IQR) | 131 (90 to 196) | 152 (102 to 232) | 114 (81 to 165) | 127 (88 to 187) | 145 (101 to 217) | 113 (80 to 160) | 259 (223 to 337) | 266 (226 to 354) | 249 (220 to 307) |
LDLdirect, mg/dL, median (IQR) | 111 (86 to 139) | 109 (84 to 136) | 112 (88 to 142) | 108 (83 to 138) | 106 (80 to 136) | 111 (86 to 139) | 119 (92 to 146) | 118.5 (93 to 145) | 120 (91 to 147) |
Subgroup based on LDLdirect (n, %) | |||||||||
LDL subgroup 1 (LDL < 70 mg/dL) | 581 (11.2%) | 357 (13.9%) | 224 (8.5%) | 287 (13.3%) | 164 (15.4%) | 123 (11.2%) | 83 (9.3%) | 64 (10.9%) | 19 (6.3%) |
LDL subgroup 2 (LDL ≥ 70 mg/dL) | 4617 (88.8%) | 2213 (86.1%) | 2404 (91.5%) | 1876 (86.7%) | 898 (84.6%) | 978 (88.8%) | 806 (90.7%) | 524 (89.1%) | 282 (93.7%) |
Subgroup based on TG (n, %) | |||||||||
TG subgroup 1 (TG < 175 mg/dL) | 3566 (68.6%) | 1517 (59.0%) | 2049 (78.0%) | 1546 (71.5%) | 669 (63.0%) | 877 (79.7%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) |
TG subgroup 2 (TG 175–400 mg/dL) | 1330 (25.6%) | 819 (31.9%) | 511 (19.4%) | 542 (25.1%) | 336 (31.6%) | 206 (18.7%) | 758 (85.3) | 489 (83.2%) | 269 (89.4%) |
TG subgroup 3 (TG > 400 mg/dL) | 302 (5.8%) | 234 (9.1%) | 68 (2.6%) | 75 (3.5%) | 57 (5.4%) | 18 (1.6%) | 131 (14.7%) | 99 (16.8%) | 32 (10.6%) |