Table 2 Allelic distribution of previously known APOC3 rare variants and their association with TG, HDL-C, and CAD
Variant | Carrier | Non-Carrier | % Carriers | Mean TG (mg/dL) Carrier/Non-carrier | Mean HDL-C (mg/dL) Carrier/Non-carrier | CAD Among Carriers | CAD Among Non-carriers | Odds Ratio/CI/P (CAD) |
|---|---|---|---|---|---|---|---|---|
rs373975305 (IVS1-2G-A) | 16 | 390,916 | 0.004 | 129.8/164.2 (−21%) | 46.5/45.4 (2.4%) | 0/16 | 20,145/370771 | 0.56 95%CI (0.03–9.30); p = 0.684 |
rs76353203 (R19X) | 56 | 390,876 | 0.014 | 84.5/163.4 (−48.3%) | 60.5/45.7 (32.4%) | 5/51 (8.9%) | 20,156/370720 | 1.80 95%CI (0.72–4.52); p = 0.208 |
rs138326449 (IVS2 + 1G-A) | 1157 | 389,775 | 0.297 | 98.9/157.9 (−37.4%) | 61.4/47.1 (30.4%) | 39/1118 (3.5%) | 20,105/369670 | 0.64 95%CI (0.47–0.88); p = 0.007 |
rs147210663 (A43T) | 326 | 390,606 | 0.083 | 122.5/163.4 (− 25%) | 50.4/45.7 (10.3%) | 11/315 (3.5%) | 20,131/370475 | 0.64 95%CI (0.35–1.17); p = 0.150 |
rs140621530 (IVS3 + 1G-T) | 24 | 390,908 | 0.006 | 133.1/164.2 (−18.9%) | 52.9/45.4 (16.5%) | 1/23 (4%) | 30,010/360898 | 0.52 95%CI (0.07–3.87); p = 0.526 |