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Table 7 Relationships between HDL-C and clinical data

From: Predictive value of a reduction in the level of high-density lipoprotein-cholesterol in patients with non-small-cell lung cancer undergoing radical resection and adjuvant chemotherapy: a retrospective observational study

 

Baseline HDL-Ca

HDL-C fluctuationb

Characteristics

High

Low

PValue

Elevation

Reduction

PValue

Age, n (%)

 < 65

16 (13.7)

83 (70.9)

0.086

77 (65.8)

22 (18.8)

0.597

 ≥ 65

6 (5.1)

12 (10.3)

 

15 (12.8)

3 (2.6)

 

Gender, n (%)

 Female

11 (9.4)

36 (30.8)

0.297

40 (34.2)

7 (6.0)

0.162

 Male

11 (9.4)

59 (50.4)

 

52 (44.4)

18 (15.4)

 

BMI (kg/m2), n (%)

 < 24

16 (13.7)

63 (53.8)

0.563

60 (51.3)

19 (16.2)

0.307

 ≥ 24

6 (5.1)

32 (27.4)

 

32 (27.4)

6 (5.1)

 

Smoking status, n (%)

 Non-smoker

8 (6.8)

55 (47.0)

0.068

55 (47.0)

8 (6.8)

0.013

 Smoker

14 (12.0)

40 (34.2)

 

37 (31.6)

17 (14.5)

 

T stage, n (%)

 1–2

19 (16.2)

74 (63.2)

0.375

73 (62.4)

20 (17.1)

0.943

 3–4

3 (2.7)

21 (17.9)

 

19 (16.2)

5 (4.3)

 

N stage, n (%)

 0–1

17 (14.5)

45 (38.5)

0.011

45 (38.5)

17 (14.5)

0.090

 2

5 (4.3)

50 (42.7)

 

47 (40.2)

8 (6.8)

 

Disease stage, n (%)

 Stage I-II

8 (6.8)

45 (38.5)

0.350

41 (35.0)

12 (10.3)

0.760

 Stage III

14 (12.0)

50 (42.7)

 

51 (43.6)

13 (11.1)

 

Histology, n (%)

 Adenocarcinoma

15 (12.8)

71 (60.7)

0.530

67 (57.3)

19 (16.2)

0.750

 Non-adenocarcinoma

7 (6.0)

24 (20.5)

 

25 (21.4)

6 (5.1)

 

Drinking status, n (%)

 Non-drinkers

14 (12.0)

71 (60.7)

0.293

68 (58.1)

17 (14.5)

0.556

 Drinkers

8 (6.8)

24 (20.5)

 

24 (20.5)

8 (6.8)

 

Radiotherapy, n (%)

 Non-radiotherapy

21 (17.9)

85 (72.6)

0.386

83 (70.9)

23 (19.7)

0.787

 Radiotherapy

1 (1.0)

10 (8.5)

 

9 (7.7)

2 (1.7)

 

chemotherapy regimens, n (%)

 Cisplatin/carboplatin/nedaplatin + pemetrexed

15 (12.8)

71 (60.7)

0.530

72 (61.5)

14 (12.0)

0.025

 Others

7 (6.0)

24 (20.5)

 

20 (17.1)

11 (9.4)

 

Surgery type, n (%)

 Lobectomy

22 (18.8)

87 (74.4)

0.158

85 (72.6)

24 (20.5)

0.526

 Pneumonectomy

0 (0)

8 (6.8)

 

7 (6.0)

1 (0.9)

 
  1. Abbreviations: HDL-C high-density lipoprotein cholesterol, BMI Body Mass Index
  2. aComparison between baseline lipids of high and low
  3. bComparison between lipids post-chemotherapy and lipids pre-chemotherapy
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Lipids in Health and Disease

ISSN: 1476-511X