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Table 4 The effect of TG/HDL-C ratio on renal function decline in participants with eGFR < 60 mL/min/1.73 m2 at baseline

From: The effect of triglycerides to high-density lipoprotein cholesterol ratio on the reduction of renal function: findings from China health and retirement longitudinal study (CHARLS)

 

Group 1

Group 2

Group 3

TG/HDL-C < 1.60

(N = 224)

1.60 ≤ TG/HDL-C < 2.97

(N = 221)

TG/HDL-C ≥ 2.97

(N = 311)

Composite endpoint of renal function decline

  Number of cases, n (%)

35 (15.62)

46 (20.81)

69 (22.19)

  Unadjusted, OR (95 % CI)

ref.

1.42 (0.87, 2.31)

1.54 (0.98, 2.41)

  P

 

0.16

0.06

  Age and gender adjusted, OR (95 % CI)

ref.

1.46 (0.89, 2.38)

1.69 (1.07, 2.68)

  P

 

0.13

0.02

  Multivariable-adjusted, OR (95 % CI)

ref.

1.32 (0.75, 2.30)

1.90 (1.21, 3.23)

  P

 

0.33

0.02

Decline in eGFR category

  Number of cases, n (%)

33 (14.73)

42 (19.00)

62 (19.94)

  Unadjusted, OR (95 % CI)

ref.

1.36 (0.82, 2.24)

1.44 (0.91, 2.29)

  P

 

0.23

0.12

  Age and gender adjusted, OR (95 % CI)

ref.

1.39 (0.84, 2.30)

1.57 (0.98, 2.51)

  P

 

0.20

0.06

  Multivariable-adjusted, OR (95 % CI)

ref.

1.33 (0.76, 2.32)

1.89 (1.12, 3.21)

  P

 

0.32

0.02

Rapid decline in eGFR

  Number of cases, n (%)

24 (10.71)

32 (14.48)

47 (15.11)

  Unadjusted, OR (95 % CI)

ref.

1.41 (0.80, 2.48)

1.48 (0.88, 2.51)

  P

 

0.23

0.14

  Age and gender adjusted, OR (95 % CI)

ref.

1.43 (0.81, 2.53)

1.57 (0.92, 2.67)

  P

 

0.22

0.10

  Multivariable-adjusted, OR (95 % CI)

ref.

1.24 (0.30, 5.13)

3.28 (0.97, 11.10)

  P

 

0.16

0.06

> 30 % decline in eGFR

  Number of cases, n (%)

9 (4.02)

15 (6.79)

23 (7.40)

  Unadjusted, OR (95 % CI)

ref.

1.74 (0.74, 4.06)

1.91 (0.87, 4.21)

  P

 

0.20

0.11

  Age and gender adjusted, OR (95 % CI)

ref.

1.74 (0.74, 4.06)

1.89 (0.86, 4.19)

  P

 

0.20

0.12

  Multivariable-adjusted, OR (95 % CI)

ref.

1.80 (0.70, 4.60)

2.56 (1.05, 6.38)

  P

 

0.22

0.04

  1. OR odds ratio; CI confidence interval; eGFR estimated glomerular filtration rate; HDL-C high-density lipoprotein cholesterol; TG triglycerides
  2. P for trend in all multivariable-adjusted models are P < 0.05
  3. a Multivariable analysis was adjusted for age, gender, hypertension, diabetes or high blood sugar, obesity, waist circumference, smoking, drinking, history of heart disease and stroke, low-density lipoprotein cholesterol, eGFR category
  4. b Decline in eGFR category (≥ 90 [G1], 60–89 [G2], 45–59 [G3a], 30–44 [G3b], 15–29 [G4], < 15 [G5] mL/min/1.73 m2) was defined as certain decrease in eGFR category from baseline
  5. c Rapid decline in eGFR was defined as sustained decline in eGFR > 5 mL/min/1.73 m2 per year
  6. d 30 % decline in eGFR was defined as > 30 % decrease in eGFR from baseline