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Table 2 Bioactive components associated to HDL

From: High density lipoproteins and oxidative stress in breast cancer

Molecule

Roles

ApoA-I

Structural role, lipid transport, antioxidant properties, immune response, haemostasis

Lecithin-Cholesterol Acyltransferase (LCAT)

Role in HDL maturation, convertion of free cholesterol into cholesteryl ester, antioxidant properties

Paraoxonase (PON1)

Antioxidant and anti-inflammatory properties of HDL, modulation of cholesterol efflux

Phospholipase A2 (PLA2)

Platelet-activating factor-acetylhydrolase (PAF-AH)

Hydrolysis of acetyl ester at the sn-2 position of PAF.

Antioxidant properties of HDL

miRNA

Regulation of gene expression

Serum amyloid A (SAA)

Acute-phase protein

Sphingosine-1-Phosphate

(S1P)

Signaling molecule that regulate cell growth, survival and differentiation, suppression of inflammation