Skip to main content

Table 4 Effect of normal and dysfunctional HDL on breast cancer cells

From: High density lipoproteins and oxidative stress in breast cancer

HDL sample

Effect on breast cancer cells

Signaling pathways involved

Normal HDL

Decreased metastasis of MCF7 cells in the liver compared with control animals in which HDL was not injected.

 

Hypochlorite-oxidized HDL

Stimulation of cell proliferation, migration, invasion, and adhesion in vitro

Promotion of breast cancer cell pulmonary and hepatic metastasis compared with normal HDL in vivo.

Protein kinase C (PKC) pathway

Glycated HDL

Copper-oxidized HDL

Stimulation of cell proliferation, migration, invasion, and adhesion in vitro

increased capacity of adhesion to human umbilical vein endothelial cells (HUVECs) compared with normal HDL

Protein kinase C (PKC) pathway

HDL isolated from T2DM patients

Promoted cell proliferation, migration, and invasion of breast cancer cells

Promoted the metastasis capacity of breast cancer cells in vivo

Increased capacity of adhesion to human umbilical vein endothelial cells (HUVECs) compared with normal HDL

Activation of Akt, ERK, and p38 mitogen-activated protein kinase (MAPK) pathways

HDL isolated from breast cancer patients complicated with T2DM

Promoted breast cancer cell adhesion to HUVECs and stimulated higher intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1)

Activation of PKC pathway

ERK and p38 MAPK pathways